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Master Thesis

Implication des paramètres anthropomorphiques de naissance dans la pseudo-hypertension artérielle du sujet jeune en France : étude comparative cas-témoins sur la cohorte de Bordeaux

Abstract : Arterial hypertension (AH) is the main risk factor for cardio-neuro-vascular morbidity and mortality, as it reflects the central blood pressure (BP) exerted on these organs. In young subjects, there are forms of systolic pseudo-HTA, with a dissociation between the BP value measured with the blood pressure cuff and the BPc value estimated via the Sphygmocor system, linked to an excessive peripheral amplification of the pulse wave by a shift in its propagation speed, amplified by the size of the subjects. In addition, in cases of abnormal fetal development (prematurity, low birth weight), an excess risk of peripheral hypertension was observed. We hypothesized that in a population of young subjects (<35 years of age) with pseudo-HTA, there might be a difference in birth weight compared with true young hypertensives; secondary hypotheses related to birth size and head circumference, and prematurity. Methods: a retrospective descriptive observational statistical case-control study in a population of subjects suspected of having hypertension and reclassified as true (cases) or false (controls) hypertension according to estimated BPc. Clinical data were obtained from the HTA reference center in Bordeaux. Birth parameters were reported retrospectively via a self-questionnaire. Results: 87 subjects were included, 64 males (74%); 72% essential hypertension, and 28% pseudo hypertension, with no difference in sex ratio (29.7% vs 21.7%, p=0.464). No significant difference in birth weight (3.16±0.65 kg among hypertensive subjects versus 3.11±0.81 kg; p=0.74). No significant difference in other birth parameters; however, the small number of subjects does not allow a definitive conclusion. In case of suspicion of pseudo-HTA in a young subject, it is not possible to conclude on the usefulness or not of the anamnesis of the perinatal parameters.
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https://dumas.ccsd.cnrs.fr/dumas-03363627
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Submitted on : Monday, October 4, 2021 - 9:54:09 AM
Last modification on : Tuesday, October 26, 2021 - 3:21:51 AM

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Jean-Baptiste Olivier Hugo Pencalet. Implication des paramètres anthropomorphiques de naissance dans la pseudo-hypertension artérielle du sujet jeune en France : étude comparative cas-témoins sur la cohorte de Bordeaux. Sciences du Vivant [q-bio]. 2021. ⟨dumas-03363627⟩

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