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Master Thesis

Post-operative T1-2 N2b oropharyngeal squamous cell carcinoma: loco-regional control after ipsilateral or bilateral neck radiation

Abstract : Actually litterature’s data are opposing and not sufficient to decide if post-operative radiation is safe enough to be as efficient as bilateral treatment concerning contralateral neck failure in oropharyngeal squamous cell carcinoma with N2b nodal disease. It is necessary to find balance between late toxicities providing by bilateral radiation and locoregional control. We first collected data that were already existing in the litterature and wrote a review. Then we established a retrospective study in François Baclesse center and registered outcomes concerning contralateral recurrences and toxicities in a population of patients with T1-T2 N2b disease. 6 patients received unilateral treatment and 15 received bilateral treatment. None of the 21 patients failed in the contralateral neck and so loco-regional control at the end of the study was 100%. Overall survival was 76%. We collected data concerning the most common toxicities as agueusia, dysphagia, xerostomia, osteoradionecrosis, loss of weight of PEG tube.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03376070
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Submitted on : Wednesday, October 13, 2021 - 11:46:25 AM
Last modification on : Thursday, October 21, 2021 - 5:02:32 AM

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  • HAL Id : dumas-03376070, version 1

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Agnès Oliviero. Post-operative T1-2 N2b oropharyngeal squamous cell carcinoma: loco-regional control after ipsilateral or bilateral neck radiation. Human health and pathology. 2021. ⟨dumas-03376070⟩

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