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Master Thesis

Effet de la clonidine intraveineuse sur l'épargne morphinique après amygdalectomie programmée en pédiatrie

Abstract : Introduction: tonsillectomy is a frequent surgery in paediatrics, known to be painful, in which morphine sparing is an important issue, because of the obstructive indication among the concerned children. Clonidine intravenous administration at induction reduces postoperative agitation, but an analgesic effect hasn’t been clearly demonstrated in paediatrics, unlike premedication with oral clonidine in children, or intravenous administration in adults. This paper aims to assess the effect of intravenous clonidine administered at induction on morphine consumption after tonsillectomy in paediatrics. Methods: this is a monocentric, retrospective study at the Pau Hospital between 2008 and 2011. An investigation on morphine consumption in the recovery room, among patients who had or not received intravenous clonidine before a scheduled tonsillectomy, has been carried out. Results: 483 patients were included in this study. 323 patients received clonidine at induction, 160 did not. In the group clonidine, morphine consumption was 0.041 mg/kg, compared to 0.052 mg/kg in the standard group, meaning a 21% decrease in morphine consumption (p = 0.039). Agitation was less frequent in the clonidine group (6.8% versus 15.1%; p = 0.006). There was no difference in the occurrence of intraoperative hypotension (0.4% versus 0.0%, p = 1.000). Conclusion: the intravenous administration of clonidine at the induction of scheduled tonsillectomy in paediatrics seems to reduce morphine consumption in the recovery room, without argument for poor tolerance. Clinical impact of this reduction in morphine consumption has not been evaluated here.
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https://dumas.ccsd.cnrs.fr/dumas-03381874
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Submitted on : Monday, October 18, 2021 - 9:19:52 AM
Last modification on : Thursday, November 25, 2021 - 3:15:46 AM
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  • HAL Id : dumas-03381874, version 1

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Ines Fuentes. Effet de la clonidine intraveineuse sur l'épargne morphinique après amygdalectomie programmée en pédiatrie. Sciences du Vivant [q-bio]. 2021. ⟨dumas-03381874⟩

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