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Master Thesis

Computer-assisted assessment of microcirculation and long-term prognosis of patients suffering from acute coronary syndrome

Abstract : Coronary artery disease, mainly represented by acute coronary syndromes, is a high-prevalence disease. While primary angioplasty has improved patient's prognosis, the morbidity remains significant. Indeed, despite good revascularization of a culprit artery, microvascular obstruction may subsist, leading to poor myocardial reperfusion and long-term heart failure. Various methods for microcirculation assessment exist, with their own benefits and limitations. In our study, we propose to use the QuBE program, an existing computer software, to obtain a quantitative analysis of microvascular damage. From 2016 to 2018, 52 patients admitted at Grenoble Alpes University Hospital or at the Annecy Genevois Hospital for acute coronary syndrome were included in the Guardiancory study. Patient's coronary angiograms were collected at and the QuBE score was performed on the culprit artery before and after angioplasty. We found that QuBE post-PCI is highly correlated with LVEF at 6 months (p=0.005), whereas other variables like post-angioplasty TIMI flow score, post-angioplasty blush grade score, or the index of microcirculatory resistance are not. Our study confirms the previous one and shows that QuBE program is an easy to use and reliable method to assess myocardial reperfusion.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03409411
Contributor : Jean-Hugues Morneau Connect in order to contact the contributor
Submitted on : Tuesday, November 2, 2021 - 4:20:35 PM
Last modification on : Thursday, November 4, 2021 - 3:42:46 AM

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  • HAL Id : dumas-03409411, version 1

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Sara Blanc-Vannet. Computer-assisted assessment of microcirculation and long-term prognosis of patients suffering from acute coronary syndrome. Human health and pathology. 2020. ⟨dumas-03409411⟩

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