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Master Thesis

Association des paramètres vasculaires rétiniens avec le glaucome à angle ouvert et l'épaisseur des fibres nerveuses rétiniennes péripapillaires dans une population âgée : l'étude ALIENOR

Abstract : Purpose: to analyze the association of retinal vascular parameters measured with a computer-assisted program with both Open Angle Glaucoma (OAG) and Retinal Nerve Fiber Layer Thickness (RNFLT) in an elderly population. Design: population-based cohort longitudinal study. Participants: of the 963 participants of the ALIENOR baseline visit, 562 were included in this analysis. Methods: we used a computer-assisted program (Singapore “I” Vessel Assessment) to measure quantitative retinal vascular parameters (vessel caliber, vascular tortuosity, fractal dimension) from retinal photographs. RNFLT was assessed with spectral-domain optical coherence tomography (software version 5.4.7.0; Spectralis, Heidelberg Engineering Co., Heidelberg, Germany). OAG diagnosis was determined using Foster et al. classification. Main outcome measure: The associations between retinal vascular parameters and glaucoma or RNFLT at ALIENOR 1 (A1) visit and longitudinal RNFLT changes with time. Results: 42 persons (7.5%) had glaucoma in the analysis. After adjusting for age, gender, smoking status, BMI, pulsed pressure and diabetes mellitus, arteriolar and venular caliber (odds ratio [OR], 0.935 ; 95% confidence interval [CI], 0.890-0.982 ; p = 0.007 and OR: 0.927 (95%CI: 0.888-0.968), p = 0.0006 - respectively), and arteriolar fractal dimension (OR: 0.539 (95%CI: 0.302-0.962), p = 0.04) were significantly associated with OAG. Arteriolar and venular caliber were significantly associated with RNFLT at A1 visit (OR: 0.435 (95%CI: 0.212-0.658), p = 0.0002 and OR: 0.486 (95%CI: 0.307-0.666, p < 0.0001 respectively). Vascular parameters were not associated with RNFLT longitudinal changes with time. Conclusion: our study found that glaucoma is associated with specific retinal vascular features. Interestingly, our study also suggests that retinal vascular features are not associated with optic nerve head changes with time in a normal population.
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https://dumas.ccsd.cnrs.fr/dumas-03411841
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Submitted on : Tuesday, November 2, 2021 - 3:34:26 PM
Last modification on : Sunday, December 12, 2021 - 3:54:41 AM

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  • HAL Id : dumas-03411841, version 1

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Guillaume Morange. Association des paramètres vasculaires rétiniens avec le glaucome à angle ouvert et l'épaisseur des fibres nerveuses rétiniennes péripapillaires dans une population âgée : l'étude ALIENOR. Sciences du Vivant [q-bio]. 2021. ⟨dumas-03411841⟩

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