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Master Thesis

Les CAR-T Cells en Onco-Hématologie : perspectives de mise en place dans un Centre Hospitalier

Abstract : CAR-T Cell therapy is a new form of immunotherapy. It is an innovative and promising treatment for patients with multi-refractory hematological diseases. Currently, three CAR-T Cells have been granted Marketing Authorization in France for the treatment of lymphoma and acute leukemia. Many clinical trials are underway. Because of their dual status as Genetically Modified Organisms (GMO) and drugs, their circuit is specific and requires special logistics. The growing activity of the clinical hematology department of the Hospital Center (CH) of the Basque Coast and its geographical location have led our medical and pharmaceutical teams to consider setting up this activity within the CH. In order to evaluate the feasibility of such a project, we first wished to identify retrospectively over the years 2019 and 2020 the patients who would have been eligible for a treatment by CAR T Cells within the hospital in the indications of diffuse large cell B lymphoma and mantle cell lymphoma. We then wished to evaluate whether our institution met the criteria necessary to set up such an activity. The number of patients identified and their characteristics, but also the potential future indications for CAR-T Cells, are arguments in favour of setting up this circuit. This would facilitate patient access to this treatment in the region. In addition, our institution has the basis for the regulatory and logistical requirements necessary for its implementation. The discussion of the initiation of such a project in the coming years seems to have all its interest and would allow an optimal care of the patients.
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Master Thesis
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Submitted on : Tuesday, November 16, 2021 - 11:26:22 AM
Last modification on : Friday, December 17, 2021 - 3:47:07 AM


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  • HAL Id : dumas-03430409, version 1



Margaux Malassigné. Les CAR-T Cells en Onco-Hématologie : perspectives de mise en place dans un Centre Hospitalier. Sciences du Vivant [q-bio]. 2021. ⟨dumas-03430409⟩



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