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Master Thesis

Clinical and electrophysiological characterization of essential tremor in children and adolescents

Abstract : Context: essential tremor (ET) is the most common movement disorder in general population. ET affects people at any age, with a bimodal repartition of onset in early childhood (even in neonates) and late adulthood. ET has mostly been studied in adults. Little is known about the specificities of electromyography (EMG) and the functional and psychosocial impact of the tremor in ET-affected children. Objective: the purpose of our study was to characterize the specificities of ET in children and the impact of the disease on their development and well-being. Method: we enrolled a cohort of 18 children and adolescents with ET, and studied the characteristics of their tremor by clinical examination and EMG. The impact of the tremor on several aspect of daily life was assed using 3 questionnaires: the Fahn Tolosa Marin rating scale for the severity of the tremor, the Tremor Disability Questionnaire for the functional impairment and the Pediatric Quality of Life inventory for the impact on health, psychological well-being and social life. Results: tremor was characterized by a median age of onset of 6 years, with bilateral upper limb localization in all patients, other body parts involvement in 47%, ET family history in 61%, and mean frequency on the EMG of 7.6 Hz. No significant difference was found according to age of onset, sex, ET family history, age at examination or duration of disease. A frequent association with myoclonus was observed. Functional impairment concerned all patients, with a mean 28% of incapacity. Quality of life was also impaired, and was significantly worse for girls, especially in the emotional scale. Discussion: tremor in our patients did not differ significantly from tremor in adults with ET on the EMG examination except for the frequent presence of myoclonus, but was often less severe and rarely involved head, lower limbs or trunk. Even though young patients seldom consult for tremor, ET has a significant impact on affected children and adolescents and should be carefully assessed.
Document type :
Master Thesis
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Contributor : Faculté de Médecine Um Connect in order to contact the contributor
Submitted on : Thursday, November 18, 2021 - 5:12:27 PM
Last modification on : Friday, November 26, 2021 - 3:15:47 AM
Long-term archiving on: : Saturday, February 19, 2022 - 7:52:17 PM


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  • HAL Id : dumas-03435444, version 1



Julie Piarroux. Clinical and electrophysiological characterization of essential tremor in children and adolescents. Human health and pathology. 2021. ⟨dumas-03435444⟩



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