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Master Thesis

Apport de l'analyse de texture pour le sous-typage des adénomes hépatocellulaires

Abstract : Objectives: non-invasive subtyping of hepatocellular adenomas (HCA) remains challenging for several subtypes, thus carrying different levels of risks and management. The goal of this study is to devise a multivariable diagnostic model based on basic clinical features (age and sex) combined with MRI-radiomics and to evaluate its diagnostic performance. Methods: this single-center retrospective case-control study included 84 HCA in 62 patients. Four MR-sequences (T2w and fat-saturated T1w images) were explored; volumes of interest were manually delineated in adenomas and 39 radiomics features (RF) were extracted (LIFEx, v5.10). Mann-Whitney U-tests were used to detect categorical variables correlating with adenoma subtypes: HNFα-inactivated adenomas (H-HCA), pure inflammatory adenomas (IHCA), ß-catenin-mutated adenomas (ß-HCA), ß-catenin-mutated inflammatory adenomas (ß-IHCA) and Sonic Hedgehog adenomas (sh-HCA). The prognostic scores of four classification models including clinical features (CF model), volume feature only (VF model), MRI-radiomics features including volume (RF model) and all features (CF+RF model) were assessed using a cross-validated Logistic Regression algorithm. Results: Different HCA subgroups could be distinguished with balanced accuracies of 80.1% ([ß- HCA+ß-IHCA] vs. IHCA; CF+RF model), 85.2% (IHCA vs. sh-HCA; CF+RF model), 83.9% ([ß- HCA+ß-IHCA] vs. sh-HCA; CF+RF model), 80.4% (ß-IHCA vs. IHCA; RF model), and 78% ([H- HCA + IHCA] vs. [ß-HCA + ß-IHCA + sh-HCA]; CF+RF model). Conclusion: using a model including clinical features and MRI-radiomics, HCA subtypes could be distinguished, especially ß-IHCA vs. IHCA and subtypes with a low risk of complication, i.e., H- HCA and I-IHCA, compared to the others. Future HCA studies enrolling more patients will further test the validity of the model.
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https://dumas.ccsd.cnrs.fr/dumas-03439101
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Submitted on : Monday, November 22, 2021 - 10:10:09 AM
Last modification on : Friday, December 17, 2021 - 3:47:07 AM
Long-term archiving on: : Wednesday, February 23, 2022 - 6:23:10 PM

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  • HAL Id : dumas-03439101, version 1

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Guillaume Delclaux. Apport de l'analyse de texture pour le sous-typage des adénomes hépatocellulaires. Sciences du Vivant [q-bio]. 2021. ⟨dumas-03439101⟩

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