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Master Thesis

Comparaison de la morbidité et de la mortalité de la transplantation hépatique chez les malades atteints de maladie vasculaire porto-sinusoïdale avec hypertension portale avec celle des malades atteints de cirrhose

Abstract : Porto-sinusoidal vascular disease (PSVD) is a liver disease that may be associated with portal hypertension. Orthotopic liver transplantation (OLT) is a therapeutic option in patients with refractory ascites or liver dysfunction. However, little is known about morbidity and mortality of OLT for PSVD. The aim of this study was to compare morbi-mortality after OLT in patients with PSVD vs. cirrhosis. This retrospective monocentric study compared characteristics before and after OLT of patients transplanted at Beaujon’s hospital between 2006 and 2018 either for PSVD with portal hypertension or for cirrhosis not related to hepatocellular carcinoma, hepatitis C, cholestatic or autoimmune liver disease (since recurrence can occur after OLT). Among 1056 liver transplantations, 38 were performed for PSVD and 324 for cirrhosis. Patients with PSVD had more frequently an history of portal thrombosis, or of previous transplantation, and a better liver function. They underwent more often multiple transplantation, and developed more often vascular complications after transplantation. No variable was able to predict mortality after OLT in patients with PSVD; only multiple transplantation tended to be associated with a poorer prognosis. When restricting the analyses to patients undergoing single liver transplantation, survival after OLT was similar between patients with PSVD and cirrhosis. In conclusion, OLT is a good therapeutic option for patients with PSVD and iterative and uncontrolled complications of portal hypertension or liver insufficiency with results comparable to those of patients with cirrhosis.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03464546
Contributor : Université Paris Descartes - Scd Connect in order to contact the contributor
Submitted on : Friday, December 3, 2021 - 12:13:59 PM
Last modification on : Saturday, January 8, 2022 - 3:09:34 AM

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  • HAL Id : dumas-03464546, version 1

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Héloïse Giudicelli-Lett. Comparaison de la morbidité et de la mortalité de la transplantation hépatique chez les malades atteints de maladie vasculaire porto-sinusoïdale avec hypertension portale avec celle des malades atteints de cirrhose. Médecine humaine et pathologie. 2020. ⟨dumas-03464546⟩

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