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Master Thesis

Modulation des propriétés mécaniques des nanoparticules, et leurs impacts sur les mécanismes biologiques

Abstract : Nanomedicines, which are hopeful vectors for pathologies such as cancer, are the subject of more and more studies. The enthusiasm for these active substance delivery systems raises new questions: what characteristics should be taken into account in the development of a nanodrug to ensure that the active substance will reach its therapeutic target? Among the most important elements, such as size, morphology, surface charge, etc., what is the role of the mechanical properties of nanovectors? Do these properties have an impact on the biological machinery? In this manuscript, we demonstrate that the mechanical properties of nanoparticles have an undeniable influence on biological mechanisms, and that it seems essential to integrate a systematic and standardized characterization of these properties, in the development of any new nanomedicine.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03467743
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Submitted on : Monday, December 6, 2021 - 4:41:06 PM
Last modification on : Saturday, December 18, 2021 - 3:53:36 AM

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LEFOL-Lise-Anne.pdf
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  • HAL Id : dumas-03467743, version 1

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Lise-Anne Lefol. Modulation des propriétés mécaniques des nanoparticules, et leurs impacts sur les mécanismes biologiques. Sciences pharmaceutiques. 2021. ⟨dumas-03467743⟩

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