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Master Thesis

Épidémiologie de le diphthérie en Nouvelle-Calédonie

Abstract : Introduction: The increasing number of cases of isolation of Corynebacterium diphtheriae in New Caledonia, the potential severity of this infection and the consequences in terms of public health actions have prompted us to focus on this bacterial species and its local epidemiology. Material and method: A retrospective clinical study was conducted by consulting patient records for each of the 84 cases included. Among these cases, 58 were retained, for which the antibiograms were retested, the tox gene sought, the biovar determined, the strains sequenced and a phylogenetic tree carried out based on the core genome of our cohort. Results: We note a concentration of cases particularly around Nouméa and Lifou. 84% of samples were taken at skin level. Overall the strains present in the territory are sensitive to the majority of commonly used antibiotics. However, 27.9% of tetracycline-resistant strains were found. 63.7% of our strains belong to only two sublineages, few found elsewhere in the world. The vast majority of strains do not express diphtheria toxin, except for two episodes, one case and five cases, all imported from Vanuatu. Discussion: The evolution of the repositories used for the realization of antibiograms tends to make strains more often resistant without biological reality when the same technique is applied to all strains. Asymptomatic portages and incidental discoveries suggest that there is a significant number of tox - strains in New Caledonia, a potential reservoir in case of introduction of tox+ strains via Vanuatu for example. This should motivate particular attention to population immunization coverage.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03468563
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Submitted on : Tuesday, December 7, 2021 - 11:09:09 AM
Last modification on : Friday, December 17, 2021 - 3:47:07 AM

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Pharmacie_2021_Tessier.pdf
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  • HAL Id : dumas-03468563, version 1

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Ève Tessier. Épidémiologie de le diphthérie en Nouvelle-Calédonie. Sciences du Vivant [q-bio]. 2021. ⟨dumas-03468563⟩

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