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Master Thesis

P wave duration in cryptogenic stroke: a case control prospective study: VPAC study

Abstract : Introduction - Cryptogenic strokes represents a challenge for secondary prevention and identification of embolic markers is important in these patients given the effectiveness of curative anticoagulation in this indication. This study evaluated the P wave duration (PWD) a noninvasive marker in a population of patients with cryptogenic stroke compared with a stroke-free control group. Methods - Patients between 18 and 80 years old who had implantable cardiac monitor inserted between January 2019 and April 2021 for cryptogenic stroke workup were included. At the same time, a stroke-free control group was constituted by including patients admitted to department of cardiology for cardiac assessment. The primary end point was PWD measured on a 12-lead ECG with high amplification. P-wave amplitude and morphology and various echocardiographic parameters of atrial function were collected in all participants. Patients in cryptogenic stroke group were monitored over time to detect AF occurrence or stroke recurrence. Results - 95 patients were included in the stroke group and 96 in the control group. PWD was significantly increased in patients in the stroke group compared with controls. There was a linear relationship between PWD and LA surface in all patients. During follow-up, 12% of patients in the stroke group developed AF and 7 patients had recurrent stroke. There was no significant difference on any variable between those who developed AF or recurrent stroke and the others. Patients with recent and older ischemic lesions or in multiple territories had significantly prolonged P-wave duration compared with others. Conclusion: - PWD is increased in patients with cryptogenic stroke. PWD measured on a high-amplification ECG could be a new noninvasive indicator of cardioembolic risk and guide the antithrombotic strategy in this population.
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Master Thesis
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Contributor : Jean-Hugues Morneau Connect in order to contact the contributor
Submitted on : Tuesday, December 7, 2021 - 11:09:10 AM
Last modification on : Saturday, January 1, 2022 - 3:33:22 AM


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  • HAL Id : dumas-03468564, version 1
  • PPN : 257344713


Elodie Deschamps. P wave duration in cryptogenic stroke: a case control prospective study: VPAC study. Human health and pathology. 2021. ⟨dumas-03468564⟩



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