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Master Thesis

Lactate de sodium hypertonique versus sérum salé hypertonique dans un modèle animal de traumatisme crânien diffus

Abstract : Introduction: Traumatic brain injury (TBI) is responsible for significant morbi-mortality, which often occurs in a young population. Hypertonic sodium lactate (HSL) appears to be an interesting neuro-protective treatment because of its anti-edematous action, but also because of its metabolic and vascular effects. Our objective is to evaluate the effects of post-traumatic administration of HSL by MRI. Method: Three groups of 10 traumatized rats and one control group were analyzed. MRI measurements were performed in the immediate post-traumatic period, 150 minutes and 7 days after. The different treatments, HSL, hypertonic saline solution (HSS), and isotonic saline solution were injected over 2 hours just after TBI. Blood gases, osmolarity, sodium, chloride and lactate serum concentrations were also measured. Results: Blood samples confirm the expected osmolarity and lactate increase in the lactate and SSH groups, respectively 319.7 7.58 mOsm/L; 315.5 5.36 mOsm/L, in similar proportions. Measurements of apparent water diffusion coefficient, vessel size index, blood volume fraction, and brain tissue oxygen saturation did not varysignificantly between the HSL and HSS treatments. Conclusion: During a moderate TBI, the neurobehavioral benefits and post-traumatic MRI changes related to HSL and described in the literature seem to be related only to hypertonicity of the solution. LSH does not seem to have a neuro-protective metabolic or vascular effect.
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Master Thesis
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Contributor : Jean-Hugues Morneau Connect in order to contact the contributor
Submitted on : Tuesday, December 7, 2021 - 12:13:58 PM
Last modification on : Saturday, January 1, 2022 - 3:33:23 AM


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  • HAL Id : dumas-03468743, version 1
  • PPN : 243280343


Pierre Fricault. Lactate de sodium hypertonique versus sérum salé hypertonique dans un modèle animal de traumatisme crânien diffus. Médecine humaine et pathologie. 2020. ⟨dumas-03468743⟩



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