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Master Thesis

Facteurs influençant les index de perfusion myocardique en tomoscintigraphie influence des polluants atmosphériques : résultats intermédiaires de l’étude Evaperf pollution

Abstract : Air pollution leads to cardiovascular morbidity and mortality, in part through alteration of endothelial function from epicardial arteries to coronary microvascular. Our team has developed a finer analysis technique of myocardial perfusion exploring the entire coronary tree by myocardial scintigraphy. The objective was to specify determinants of perfusion indices whose PM2.5 fine particles influence. Any outpatient who came to perform myocardial scintigraphy at University Hospital of Grenoble was included from July, 2017 to March, 2019. Perfusion analysis was done by calculating Summed Stress Score (SSS), Summed Rest Stress (SRS) and Myocardial perfusion entropy to stress (MPE stress) in blind clinical data. Exposure to PM2.5 was estimated via Atmo Aura sensors. This work focuses on the first 270 patients. The correlation was negative between MPE stress and SSS (p <10-4), SRS (p <10-4). Predictors of elevating SSS were diabetes (p = 0.03), myocardial infarction (p <10-4). MPE stress increased with a BMI ≥ 35 kg/m2 (p = 0.04), and was lower among women (p <10-4), patients under ICE / ARB II (p = 0.03), or diabetic patients (p = 0.007). Chronic PM2.5 exposure was associated with elevation of SSS (p = 0.02) and SRS (p = 0.008) in the adjusted model but was not associated with MPE (p = 0,13). These associations diminished after adjusting with other clinical factors. MPE Stress was negatively correlated with SSS and SRS. The analysis at the end of the study may confirm the suggested associations.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03469272
Contributor : Jean-Hugues Morneau Connect in order to contact the contributor
Submitted on : Tuesday, December 7, 2021 - 3:44:08 PM
Last modification on : Saturday, January 1, 2022 - 3:33:59 AM

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  • HAL Id : dumas-03469272, version 1
  • PPN : 235630152

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Océane Bouchot. Facteurs influençant les index de perfusion myocardique en tomoscintigraphie influence des polluants atmosphériques : résultats intermédiaires de l’étude Evaperf pollution. Médecine humaine et pathologie. 2019. ⟨dumas-03469272⟩

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