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Master Thesis

Prise de décision en contexte d’apprentissage par renforcement dans les troubles bipolaires : étude de la sensibilité à la récompense et à la punition en fonction du sous-type de trouble bipolaire

Abstract : Phenotypic expression of bipolar disorder (BD) is wide and two bipolar subtypes prevail, bipolar 1 subtype (BD-I) and bipolar 2 subtype (BD-II). Decision-making and reward processing, which are involved into goal-directed behaviors, are largely documented into BD, related to the relevance of these behaviors (increased or decreased) during thymic relapse. Most of these studies doesn’t taking account this widely phenotypic expression, and include BD patients of both groups, or only BD-I patients. Very few studies investigate reward and punishment learning according to BD subtype. To date, neurobiology of BD-II still largely unknown, and some authors think about distinct pattern activation between BD-I and BD-II. Our study examines decision making during appetitive and punitive reinforcement learning, relative to BD subtype and healthy subjects. Our results showed reward hyposensitivity in BD than healthy subjects, but subtype didn’t differ. Nonetheless, we didn’t show difference in punishment processing between BD patients and healthy subjects, with a difference in punishment learning relative to BD subtype, with lower performance in BD-II, compared with BD-I. To date, no studies examine punishment processing in neuroimaging in BD-II, which could constitute a trait-dependent-marker of BD-II.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03469317
Contributor : Jean-Hugues Morneau Connect in order to contact the contributor
Submitted on : Tuesday, December 7, 2021 - 3:59:18 PM
Last modification on : Saturday, January 1, 2022 - 3:33:59 AM

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  • HAL Id : dumas-03469317, version 1
  • PPN : 235286583

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Arnaud Pouchon. Prise de décision en contexte d’apprentissage par renforcement dans les troubles bipolaires : étude de la sensibilité à la récompense et à la punition en fonction du sous-type de trouble bipolaire. Médecine humaine et pathologie. 2019. ⟨dumas-03469317⟩

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