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Master Thesis

Les carcinomes basocellulaires de la paupière : analyse statistique du taux de récidive à 6 ans selon les marges histologiques et les sous-types histologiques du point de vue de l’ophtalmologiste

Abstract : Background. Basocellular carcinoma (BCC) is the most frequent skin tumor. Current recommendations do not indicate histological safety margins to be observed to prevent recurrence after tumor excision. Objective. The main goal of this study was to assess the recurrence rate at 6 years of eyelid CBCs function of the histological subtype and histological safety margins. Patients and methods. We conducted a monocentered retrospective study of eyelid BCC operated between 2010 and 2016 in the University Hospital of Caen, France. Histological subtypes along with a panel of anatomopathological were studied. Moreover, lateral, and inner surgical margins were also measured. Results. A total of 98 BCCs were included, among which 5 recurred (~5%). The sample was divided in two groups function of the risk or the status of recurrence. Consistent with the literature, severe BCCs were associated with a higher risk of recurrence and were mostly localized on the lower eyelid. Recurring BCCs showed lateral surgical margins significantly inferior (0.4 mm) when compared with non-recurring BCCs (2.35 mm). Recurring tumors were mostly of mixt histological subtypes (infiltrating and nodular, adamantanoid). Discussion. Our results are consistent with the literature, in which several studies recommend histological safety margins superior to 2 mm in the surgical excision of severe BCCs.
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https://dumas.ccsd.cnrs.fr/dumas-03523427
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Submitted on : Wednesday, January 12, 2022 - 4:28:06 PM
Last modification on : Saturday, January 15, 2022 - 3:32:42 AM

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  • HAL Id : dumas-03523427, version 1

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Mouhamadou Touré. Les carcinomes basocellulaires de la paupière : analyse statistique du taux de récidive à 6 ans selon les marges histologiques et les sous-types histologiques du point de vue de l’ophtalmologiste. Médecine humaine et pathologie. 2021. ⟨dumas-03523427⟩

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