HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Master Thesis

Les chéloïdes, conception d’une étude clinique visant à évaluer la sécurité et l’efficacité d'un traitement, quels paramètres choisir ?

Abstract : Background : Keloids are benign fibroproliferative dermal tumours and chronic skin disorder that result from an abnormal fibrous wound healing process. Objective: This thesis aims to provide a better understanding of the pathology and to explore the encountered challenges and parameters used in the design of clinical trials conducted in this field. Method: A state of the art of the keloid disease and of the current treatments has been performed. Also, a review of published and registered qualitative and clinical studies was conducted in 2020. Results: Two qualitative studies were identified and used to generate a conceptual model of the disease. This model highlights the impact of the disease on the quality of life of patients living with keloids. 215 clinical studies published between 1995 and 2020 and 23 studies registered in the last 5 years were analysed to identify the endpoints and the tools used. As a result, 15 questionnaires and measuring devices were described and compared on the basis of their psychometric or clinimetric properties.
Document type :
Master Thesis
Complete list of metadata

https://dumas.ccsd.cnrs.fr/dumas-03552693
Contributor : Santé Rennes 1 Connect in order to contact the contributor
Submitted on : Wednesday, February 2, 2022 - 1:49:45 PM
Last modification on : Wednesday, March 16, 2022 - 3:37:29 AM
Long-term archiving on: : Tuesday, May 3, 2022 - 7:06:35 PM

File

MICHEL_Anne-sophie.pdf
Files produced by the author(s)

Identifiers

  • HAL Id : dumas-03552693, version 1

Collections

Citation

Anne-Sophie Michel. Les chéloïdes, conception d’une étude clinique visant à évaluer la sécurité et l’efficacité d'un traitement, quels paramètres choisir ?. Sciences du Vivant [q-bio]. 2021. ⟨dumas-03552693⟩

Share

Metrics

Record views

5

Files downloads

0