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Master Thesis

Performances des tests ELISA anti-BP180 et anti-BP230 dans le diagnostic de pemphigoïde des muqueuses avec atteinte endobuccale stricte

Abstract : The aim of this study was to evaluate the performance of ELISAs tests routinely prescribed in the diagnostic of mucous membrane pemphigoid limited to buccal mucosa. For this purpose, we conducted a retrospective monocentric diagnostic study based on the results of the anti-BP180 and anti-BP230 ELISAs tests performed in the diagnosis of DBAI, between January 2010 and December 2021, in the Medical Activity Unit of Mucosal Pathologies of the Bordeaux University Hospital. In order to evaluate their performance, we calculated the sensitivity (Se), specificity (Sp), positive predictive value (PPV) and négative predictive value (NPV) of the anti-BP180 and anti-BP230 ELISAs. 58 patients were included, 35 of whom had mucosal pemphigoid with strict buccal involvement. The control group consisted of 23 patients who had another autoimmune bullous dermatosis. For BP180 : Se = 26%, Sp = 70%, PPV = 56%, NPV = 38%. For BP230 : Se = 0%, Sp = 96%, PPV = 0% and NPV = 39%. The analysis of the results seems to show a poor performance of BP180 and BP230 ELISAs tests for the diagnosis of PM with strict endobuccal involvement.
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https://dumas.ccsd.cnrs.fr/dumas-03578152
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Submitted on : Thursday, February 17, 2022 - 9:40:14 AM
Last modification on : Friday, February 18, 2022 - 3:37:25 AM
Long-term archiving on: : Wednesday, May 18, 2022 - 6:27:27 PM

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Guillaume Rougier. Performances des tests ELISA anti-BP180 et anti-BP230 dans le diagnostic de pemphigoïde des muqueuses avec atteinte endobuccale stricte. Sciences du Vivant [q-bio]. 2022. ⟨dumas-03578152⟩

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