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Master Thesis

Insight into the relationship between forced vital capacity and transfer factor of the lung for carbon monoxide in patients with idiopathic pulmonary fibrosis

Abstract : Background: FVC and DLCO are the most useful physiological parameters to assess idiopathic pulmonary fibrosis (IPF). They are expressed as percentage of reference value or Z-score, and the use of Global Lung Initiative (GLI) equations is now recommended. The objectives were to describe the relationship between FVC and DLCO, and to assess the influence of the change in reference values on medical decision, namely regarding the selection of lung transplant candidates. Methods: we included all subjects diagnosed with IPF from the cohort COLIBRI-ILD. Measurements of FVC and DLCO performed at the same time were collected for each patient. Results: in 248 IPF patients with a broad range of severity, this transversal observation highlighted the nonlinear relationship between FVC and DLCO. Those results could allow us to characterise the course of FVC and DLCO throughout disease progression for a given patient. In the first stages, FVC would remain steady while DLCO would drop. In contrast, both would decline in the last stages. 17 patients switch group to be reffered to a lung transplant center when we use GLI instead of the older standards, with the cut-off limit of 40 % for DLCO or 80 % for FVC. Conclusion: DLCO seems essential in monitoring the IPF forms when FVC is preserved. The use of GLI is little more sensitive than older standards to select lung transplant candidates.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03601218
Contributor : Jean-Hugues Morneau Connect in order to contact the contributor
Submitted on : Tuesday, March 8, 2022 - 10:23:32 AM
Last modification on : Wednesday, March 9, 2022 - 3:36:32 AM

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  • HAL Id : dumas-03601218, version 1

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Salomé Nussbaum. Insight into the relationship between forced vital capacity and transfer factor of the lung for carbon monoxide in patients with idiopathic pulmonary fibrosis. Human health and pathology. 2021. ⟨dumas-03601218⟩

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