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Master Thesis

Évaluation métabolique de l'arrêt du métronidazole chez les patients suivis pour une acidurie méthylmalonique ou propionique

Abstract : Objective: To assess whether stopping the use of Metronidazole has an impact on the laboratory test results of the patients with methymalonic aciduria (AMM) or propionic aciduria (AP). Methods: Metronidazole treatment of patients followed at Necker hospital for AMM or AP was stopped between November 2019 and February. The test parameters have been studied by comparing retrospectively the blood test and urine results done before the end of treatment (time 0) and after completion of treatment (time 1). The main marker was propionylcamitine (C3). The secondary markers were urinary methymalonic acid (AMMu) for the AMM and the 2-méthylcitric acid (2MC) and 3-hydroxypropionic acid (3OHP) for the AP. The obtained results at time 0 et at time 1 have been then compared using the nonparametric Wilcoxon test. Results: 15 patients have been included (6 men and 9 women between the ages of 1 and 30 yrs old). The results do not show a significant difference between the levels of C3 before and after the use of métronidazole (W=87; p=0.132). There also was not a significant difference of levels for the AMMu (W=12; p=0.844) le 2MC (W=22; p=0.641) ou le 3OHP (W=31; p=0.078). Conclusion: No significant changes in C3, AMMu, 2MC or 3OHP levels after stopping metronidazole was shown. These results support the current trend towards limiting the long-term prescription of antibiotics in these patients.
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Master Thesis
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Submitted on : Wednesday, March 9, 2022 - 2:56:47 PM
Last modification on : Wednesday, May 11, 2022 - 4:40:30 AM


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Guillaume Husset. Évaluation métabolique de l'arrêt du métronidazole chez les patients suivis pour une acidurie méthylmalonique ou propionique. Médecine humaine et pathologie. 2021. ⟨dumas-03602914⟩



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