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Master Thesis

Sarcopénie et myostéatose : quel impact fonctionnel à moyen terme pour une cohorte réanimatoire ?

Abstract : PURPOSE Sarcopenia and myosteatosis are critical factors for numerous conditions. They are well-known prognostic factors in the elderly and in an oncologic population, which are now used for various pathologies. They are also proving to be major factors to predict mortality in intensive care patients. Few studies are currently focusing on evaluating the functional impact after intensive care discharge and none has considered sarcopenia and myosteatosis as prognostic factors. The aim of our study is to determine whether sarcopenia and myosteatosis are reliable prognostic factors for the mid-term functional impact in critical patients a few months after ICU discharge. MATERIALS AND METHODS We carried out a retrospective monocentric study using CT performed at ICU admission and/or 3 months after discharge in order to assess sarcopenia and myosteatosis in 43 patients with critical illnesses who underwent a multidisciplinary evaluation on DH. These data were compared to the main patients’ characteristics at ICU admission and stay and to functional assessments using Hand-Grip Test, 6-Minute Walking Test, Maximal Inspiratory Pressure. RESULTS We found a good correlation of both SMI and SMD for T4 and L3 levels. SMI was correlated to HGT, while SMD was correlated to 6MWT, which are both functional tests recommended in the EWGSOP’s algorithm to diagnose sarcopenia. MIP was correlated both to SMI and SMD, but also to other functional tests. CONCLUSION We confirmed the reliability of thoracic CT to assess sarcopenia and myosteatosis. We found that SMI and SMD are independent though complementary predictive factors of functional impact at mid-term on ICU patients. MIP might be a useful tool for the assessment and management of sarcopenia.
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Master Thesis
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Submitted on : Wednesday, March 23, 2022 - 2:51:27 PM
Last modification on : Thursday, March 24, 2022 - 3:40:39 AM


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  • HAL Id : dumas-03617470, version 1



Margot Dressaire. Sarcopénie et myostéatose : quel impact fonctionnel à moyen terme pour une cohorte réanimatoire ?. Médecine humaine et pathologie. 2021. ⟨dumas-03617470⟩



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