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Master Thesis

Effect of a lifestyle intervention on telomere length: a systematic review and meta-analysis

Abstract : Background: we aimed to conduct a systematic review and meta-analysis to assess the effects of lifestyle intervention on telomere length (TL). Method: PubMed, Cochrane, Embase, and ScienceDirect were searched for studies reporting TL before and after a lifestyle intervention. We computed random-effects meta-analysis on TL at baseline between groups, within intervention group and control group after versus before intervention, and on changes in TL between groups. Sensitivity analyses were conducted after exclusion of studies outside funnel plots and keeping only RCT. Meta-regressions were computed to search for influential factors of TL. Results: we included 20 studies for a total of 2995 patients (mean: 50.3 years old, 77% women): 2045 individuals following an intervention and 950 controls. TL did not differ at baseline between intervention and control groups. Intervention was physical activity ± diet (n= 13 studies), diet (n= 1), stress management (n= 4), and supplementation (n= 2). The physical activity ± diet group had an increase in TL (Effect size 0.17, 95%CI 0.03 to 0.31, p= 0.020) using changes within the intervention group, whereas TL shortened in the control group (-0.32, -0.61 to -0.02, p= 0.037). TL was longer in the physical activity ± diet intervention group (0.24, 0.08 to 0.40, p= 0.004) compared to controls after the intervention. Sensitivity analysis after exclusion from meta-funnel gave similar results to only RCT. Meta-regressions demonstrated that combining strength and endurance exercise increased TL more than endurance alone (Coefficient 0.51, 95%CI 0.19 to 0.81, p= 0.004) or strength alone (0.74, 0.37 to 1.12, p= 0.001). Conclusion: a lifestyle intervention with physical activity ± diet can increase telomere length, independently of population characteristics or baseline TL. Combining strength and endurance may be the most beneficial exercise on TL.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03618307
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Submitted on : Thursday, March 24, 2022 - 11:13:35 AM
Last modification on : Saturday, March 26, 2022 - 4:13:01 AM

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Marjorie Buttet. Effect of a lifestyle intervention on telomere length: a systematic review and meta-analysis. Human health and pathology. 2021. ⟨dumas-03618307⟩

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