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Master Thesis

Efficacy of oral Ibuprofen in shoulder pain: a systematic review of randomized controlled trials

Abstract : BACKGROUND: shoulder pain is a common reason for consultation in primary care and leads in 74 % of cases to an oral NSAIDs prescription. Ibuprofen is a widely used NSAID and is also accessible to self medication, which raises questions about its benefits/risks of its use. PURPOSE: assess efficacy of oral Ibuprofen in shoulder pain. METHODS: a systematic review was carried out up to August 2021. It selected randomized controlled trials (RCT) comparing the efficacy of oral Ibuprofen with placebo or other antalgic drugs in shoulder pain. Efficacy including: efficiency on pain, variation in degree of pain, time to reach relief, patient’s satisfaction, change in quality of life, change in range of motion. Were not included studies concerning inflammatory pain caused by auto-immun or auto inflammatory diseases and fractures. RESULTS: four RCT were included and analyzed for risk of bias. Outcomes measurement, pathologies and antalgic drugs interventions were too heterogeneous to conduct a meta-analysis. One RCT found that Ibuprofen leads to pain and functional disability improvement versus Acetaminophen in rotator cuff pain with a moderate risk of bias. Another one found no significant difference between Ibuprofen and Diclofenac in shoulder periarthritis with a high risk of bias. Lastly, a RCT with low risk of bias, did not find any difference in improvement between conventional and sustained release ibuprofen tablets. CONCLUSION: although Ibuprofen is widely prescribed in primary care, there is no solid evidence of its efficacy on shoulder pain.
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Master Thesis
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Submitted on : Tuesday, April 5, 2022 - 2:10:18 PM
Last modification on : Thursday, April 7, 2022 - 3:34:25 AM


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  • HAL Id : dumas-03631107, version 1



Marie Barriere, Laurie Cambourieux. Efficacy of oral Ibuprofen in shoulder pain: a systematic review of randomized controlled trials. Human health and pathology. 2022. ⟨dumas-03631107⟩



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