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Master Thesis

Patterns d’altération en tomographie par cohérence optique chez les patients atteints de sclérose en plaques : une étude descriptive transversale monocentrique

Abstract : Background: no studies have identified all OCT impairment patterns in MS. We studied their distribution in a population of MS patients between July 2019 and December 2021 at the University Hospital of Nîmes (France). Methods: 144 patients (288 eyes) who performed oct on the Canon HS-100® device and low contrast visual acuity were included. Results: 66.7% of patients had damage to at least one eye in OCT and only 42.4% of the eyes were considered strictly normal. Perifoveolar involvement was the most common pattern (30.2% of the eyes) followed by minimal macular ganglion cell complex (mGCC) involvement (21.5%), then "horse hoof" involvement (14.9%) and temporal peripapillary ring nerve fiber layer (pRNFL) involvement (11.5%). Homonymous patterns were found in retro-chiasmatic pseudo-tumor disorders (2.1%). Fascicular involvement was not uncommon (5.6%). Nasal pRNFL involvement was common (13.2%). Visual function was little impaired in our population since only 8% of the eyes had an abnormal visual acuity at full contrast. Conclusion: OCT disorders are very common in MS even in the early stages of the disease. The identification of the different patterns allows a better follow-up of the patients. Further studies are needed to know the evolution of these patterns over time, to identify prognostic factors and to identify factors of progression of the disease.
Mots-clés : OCT pRNFL mGCC Canon HS-100®
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03664663
Contributor : Faculté de Médecine Um Connect in order to contact the contributor
Submitted on : Wednesday, May 11, 2022 - 10:59:31 AM
Last modification on : Saturday, May 14, 2022 - 3:16:32 AM

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Nicolas Sauret. Patterns d’altération en tomographie par cohérence optique chez les patients atteints de sclérose en plaques : une étude descriptive transversale monocentrique. Médecine humaine et pathologie. 2022. ⟨dumas-03664663⟩

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