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Master Thesis

Profil des myosites auto-immunes avec ou sans atteinte pulmonaire : une étude monocentrique rétrospective de 40 patients

Abstract : Introduction: Idiopathic inflammatory myopathies (IMM) are rare diseases with clinico-biological heterogeneity. Pulmonary involvement is frequent and associated with some distinctive manifestations. The aim of this study is to describe the clinico-biological profile of patients with autoimmune myositis with and without pulmonary involvement. Methods: This is a retrospective descriptive study, including patients with idiopathic inflammatory myopathies and a positive antibody at Grenoble Alpes University Hospital from 2010 to 2020. Results: Forty patients were included, the majority were women. The anti-JO1 autoantibody was the most frequently found (37.5%). The prevalence of pulmonary involvement was 70%. Regarding both groups, there was a significant difference between myositis subtypes in patients with pulmonary involvement (p <0.05). Mechanics' hands and Raynaud's syndrome were the extra-respiratory signs significantly more present in the group with lung involvement (p <0.05), in contrast to CPK which was lower (p <0.05). Glucocorticoids and rituximab were significantly more used in the lung involvement group (p <0.05). The 5-year survival rate was 76.2% in patients with lung involvement and 100% in patients without lung involvement without significant difference. Conclusion: We find a high prevalence of lung involvement probably explained by the presence of many cases of anti-synthetase syndrome. Our study highlights a lesser severity of muscle involvement in cases of myositis with lung disease, which deserves to be confirmed in a larger study.
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Master Thesis
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Contributor : Jean-Hugues Morneau Connect in order to contact the contributor
Submitted on : Wednesday, May 11, 2022 - 5:17:18 PM
Last modification on : Friday, May 13, 2022 - 3:37:31 AM


  • HAL Id : dumas-03665444, version 1


Orlane Chol. Profil des myosites auto-immunes avec ou sans atteinte pulmonaire : une étude monocentrique rétrospective de 40 patients. Médecine humaine et pathologie. 2022. ⟨dumas-03665444⟩



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