Harnessing Forward Multiple Scattering for Optical Imaging Deep Inside an Opaque Medium - Institut Langevin Accéder directement au contenu
Article Dans Une Revue Nature Communications Année : 2024

Harnessing Forward Multiple Scattering for Optical Imaging Deep Inside an Opaque Medium

Résumé

As light travels through a disordered medium such as biological tissues, it undergoes multiple scattering events. This phenomenon is detrimental to in-depth optical microscopy, as it causes a drastic degradation of contrast, resolution and brightness of the resulting image beyond a few scattering mean free paths. However, the information about the inner reflectivity of the sample is not lost; only scrambled. To recover this information, a matrix approach of optical imaging can be fruitful. Here, we report on a de-scanned measurement of a high-dimension reflection matrix R via low coherence interferometry. Then, we show how a set of independent focusing laws can be extracted for each medium voxel through an iterative multi-scale analysis of wave distortions contained in R. It enables an optimal and local compensation of forward multiple scattering paths and provides a three-dimensional confocal image of the sample as the latter one had become digitally transparent. The proof-of-concept experiment is performed on a human opaque cornea and an extension of the penetration depth by a factor five is demonstrated compared to the state-of-the-art.
Fichier principal
Vignette du fichier
main.pdf (37.12 Mo) Télécharger le fichier
main (1).pdf (37.12 Mo) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03981863 , version 1 (10-02-2023)
hal-03981863 , version 2 (17-10-2023)
hal-03981863 , version 3 (13-08-2024)

Licence

Identifiants

Citer

Ulysse Najar, Victor Barolle, Paul Balondrade, Mathias Fink, Claude Boccara, et al.. Harnessing Forward Multiple Scattering for Optical Imaging Deep Inside an Opaque Medium. Nature Communications, 2024, 15 (1), pp.7349. ⟨10.1038/s41467-024-51619-9⟩. ⟨hal-03981863v3⟩
247 Consultations
23 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More