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Master Thesis

Inhibition de la lactation dans le Post-partum : Bromocriptine vs Cabergoline. Étude prospective, comparative réalisée auprès de 99 patientes à Necker et Port-Royal

Abstract : Objective : To compare the efficacy and safety of a single dose of cabergoline 1mg with that of 2,5mg of bromocriptine, twice daily, during 21 days. Methods and subjects: A prospective, comparative study on 2 parallel groups (Bromocriptine 52 women vs Cabergoline 47 women). The 99 women, not wishing to lactate, had to fill out 2 questionnaires. One during their hospital stay and the other 21 days after the beginning of the treatment. Main outcomes: A higher rate of adverse events was reported within the bromocriptine's group (36%,19/52) compared to the cabergoline group (17%,8/47), . Complete success was achieved in 78% of the women treated by bromocriptine and in 85% with those under cabergoline (p=0,2). 13 women, out of the 52, (25%) stopped taking their treatment, because of intolerance and adverse events. After 21 days of treatments, rebound breasts symptomatology occurred in both groups in 4%. Conclusions: A single dose of cabergoline is at leasat as effective as bromocriptine 2,5mg twice daily for 21 days in preventing puerperal lactation. Because of the considerably lower rate of adverse events and a higher rate of success, cabergoline should be the drug of choice for lactation inhibition. Nevertheless, dopamine agonists, should be prescribe with great care, because of possible dangerous events.
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https://dumas.ccsd.cnrs.fr/dumas-00623068
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Submitted on : Tuesday, September 13, 2011 - 3:05:29 PM
Last modification on : Friday, June 26, 2020 - 4:44:02 PM
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  • HAL Id : dumas-00623068, version 1

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Brune Galouzeau de Villepin. Inhibition de la lactation dans le Post-partum : Bromocriptine vs Cabergoline. Étude prospective, comparative réalisée auprès de 99 patientes à Necker et Port-Royal. Gynécologie et obstétrique. 2011. ⟨dumas-00623068⟩

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