M. Levy, M. Fink, and J. Marshall, 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference, Critical Care Medicine, vol.31, issue.4, pp.1250-1256, 2001.
DOI : 10.1097/01.CCM.0000050454.01978.3B

G. S. Martin, D. M. Mannino, S. Eaton, and M. Moss, The Epidemiology of Sepsis in the United States from 1979 through 2000, New England Journal of Medicine, vol.348, issue.16, pp.1546-1554, 2000.
DOI : 10.1056/NEJMoa022139

D. Annane, P. Aegerter, M. C. Jars-guincestre, and B. Guidet, Current Epidemiology of Septic Shock, American Journal of Respiratory and Critical Care Medicine, vol.168, issue.2, pp.165-172, 2003.
DOI : 10.1164/rccm.2201087

D. C. Angus, W. T. Linde-zwirble, J. Lidicker, G. Clermont, J. Carcillo et al., Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care, Critical Care Medicine, vol.29, issue.7, pp.1303-1310, 2001.
DOI : 10.1097/00003246-200107000-00002

M. Levy, A. Artigas, and G. Phillips, Outcomes of the Surviving Sepsis Campaign in intensive care units in the USA and Europe: a prospective cohort study, The Lancet Infectious Diseases, vol.12, issue.12, pp.919-943, 2012.
DOI : 10.1016/S1473-3099(12)70239-6

J. M. Cavaillon, Inflammation locale et générale « Sepsis, pp.45-73, 2004.

B. Vallet, Vascular nitric oxide during sepsis: from deficiency to overproduction Adv, Sepsis, vol.1, pp.52-57, 2001.

R. M. Sharpe and C. G. Ellis, Bench-to-bedside review: microvascular dysfunction in sepsishemodynamics , oxygen transport, and nitric oxide Crit, Care, vol.7, pp.359-373, 2003.

C. Holmes, J. Russell, and K. Walley, Genetic Polymorphisms in Sepsis and Septic Shock, Chest, vol.124, issue.3, pp.1103-1118, 2003.
DOI : 10.1378/chest.124.3.1103

X. Wu, R. Guo, Y. Wang, and P. Cunningham, The role of ICAM-1 in endotoxin-induced acute renal failure, AJP: Renal Physiology, vol.293, issue.4, pp.1262-1271, 2007.
DOI : 10.1152/ajprenal.00445.2006

J. Vincent, Y. Sakr, C. Sprung, V. Ranieri, K. Reinhart et al., Sepsis in European intensive care units: Results of the SOAP study*, Occurrence in Acutely Ill Patients Investigators, pp.344-353, 2006.
DOI : 10.1097/01.CCM.0000194725.48928.3A

E. Rivers, B. Nguyen, and S. Havstad, Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock, New England Journal of Medicine, vol.345, issue.19, pp.1368-77, 2001.
DOI : 10.1056/NEJMoa010307

R. Bateman, M. Sharpe, and C. Ellis, Bench-to-bedside review: microvascular dysfunction in sepsis -hemodynamics, oxygen transport, and nitric oxide, Critical Care, vol.7, issue.5, pp.359-73, 2003.
DOI : 10.1186/cc2353

M. Parker, J. Shelhamer, and S. Bacharach, Profound but Reversible Myocardial Depression in Patients with Septic Shock, Annals of Internal Medicine, vol.100, issue.4, pp.483-90, 1984.
DOI : 10.7326/0003-4819-100-4-483

F. Jardin, T. Fourme, and B. Page, Persistent Preload Defect in Severe Sepsis Despite Fluid Loading, Chest, vol.116, issue.5, pp.1354-1363, 1999.
DOI : 10.1378/chest.116.5.1354

B. Vallet, Vascular reactivity and tissue oxygenation, Intensive Care Medicine, vol.24, issue.1, pp.3-11, 1998.
DOI : 10.1007/s001340050507

R. W. Schrier, M. D. , W. Wang, and M. D. , Acute Renal Failure and Sepsis, New England Journal of Medicine, vol.351, issue.2, pp.159-169, 2004.
DOI : 10.1056/NEJMra032401

D. Payen and C. Berton, Insuffisance r??nale aigu????: ??pid??miologie, incidence et facteurs de risque, Annales Fran??aises d'Anesth??sie et de R??animation, vol.24, issue.2, pp.134-143, 2005.
DOI : 10.1016/j.annfar.2004.11.017

S. Uchino, J. Kellum, and R. Bellomo, Acute Renal Failure in Critically Ill Patients<SUBTITLE>A Multinational, Multicenter Study</SUBTITLE>, JAMA, vol.294, issue.7, pp.813-818, 2005.
DOI : 10.1001/jama.294.7.813

N. Riedemann, R. Guo, and P. Ward, The enigma of sepsis, Journal of Clinical Investigation, vol.112, issue.4, pp.460-467, 2003.
DOI : 10.1172/JCI200319523

M. Rangel-frausto, D. Pittet, M. Costigan, T. Hwang, C. Davis et al., The Natural History of the Systemic Inflammatory Response Syndrome (SIRS), JAMA, vol.273, issue.2, pp.117-140, 1995.
DOI : 10.1001/jama.1995.03520260039030

A. Hutchinson, M. Ogletree, J. Snapper, and K. Brigham, Effect of endotoxemia on hypoxic pulmonary vasoconstriction in unanesthetized sheep, J Appl Physiol, vol.58, pp.1463-1468, 1985.

R. P. Dellinger, M. Levy, A. Rhodes, H. Gerlach, D. Annane et al., Surviving Sepsis Campaign, Critical Care Medicine, vol.41, issue.2, pp.536-555, 2012.
DOI : 10.1097/CCM.0b013e31827e83af

A. Kumar, P. Ellis, and Y. Arabi, Initiation of Inappropriate Antimicrobial Therapy Results in a Fivefold Reduction of Survival in Human Septic Shock, Chest, vol.136, issue.5, pp.1237-1248, 2009.
DOI : 10.1378/chest.09-0087

. Metnitz, C. Krenn, H. Steltzer, T. Lang, J. Ploder et al., Effect of acute renal failure requiring renal replacement therapy on outcome in critically ill patients*, Critical Care Medicine, vol.30, issue.9, pp.2051-2059, 2002.
DOI : 10.1097/00003246-200209000-00016

F. Brunkhorst, C. Engel, and F. Bloos, Intensive Insulin Therapy and Pentastarch Resuscitation in Severe Sepsis, New England Journal of Medicine, vol.358, issue.2, pp.125-164, 2008.
DOI : 10.1056/NEJMoa070716

B. Guidet, O. Martinet, and T. Boulain, Assessment of hemodynamic efficacy and safety of 6% hydroxyethylstarch 130/0.4 vs. 0.9% NaCl fluid replacement in patients with severe sepsis: The CRYSTMAS study, Critical Care, vol.16, issue.3, p.94, 2012.
DOI : 10.1186/1745-6215-12-24

URL : https://hal.archives-ouvertes.fr/inserm-00706029

A. Kumar, D. Roberts, and K. Wood, Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock*, Critical Care Medicine, vol.34, issue.6, pp.1589-1596, 2006.
DOI : 10.1097/01.CCM.0000217961.75225.E9

A. Kumar, Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: A propensity-matched analysis*, Critical Care Medicine, vol.38, issue.9, pp.1773-85, 2010.
DOI : 10.1097/CCM.0b013e3181eb3ccd

A. Perner, N. Haase, and A. Guttormsen, Hydroxyethyl Starch 130/0.42 versus Ringer's Acetate in Severe Sepsis, New England Journal of Medicine, vol.367, issue.2, pp.124-158, 2012.
DOI : 10.1056/NEJMoa1204242

J. Myburgh, S. Finfer, and R. Bellomo, Hydroxyethyl Starch or Saline for Fluid Resuscitation in Intensive Care, New England Journal of Medicine, vol.367, issue.20, pp.1901-1912, 2012.
DOI : 10.1056/NEJMoa1209759

G. Van-den-berghe, P. Wouters, F. Weekers, C. Verwaest, F. Bruyninckx et al., Intensive Insulin Therapy in Critically Ill Patients, New England Journal of Medicine, vol.345, issue.19, pp.1359-1367, 2001.
DOI : 10.1056/NEJMoa011300

. Recommandations-de-bonne-pratique, Diagnostic et antibiothérapies des infections urinaires bactériennes communautaires chez l'adulte ? Affsaps, 2008.

M. Paul, K. Soares-weiser, and L. Leibovici, beta lactam monotherapy versus beta lactam-aminoglycoside combination therapy for fever with neutropenia: systematic review and meta-analysis, BMJ, vol.326, issue.7399, pp.1111-1116, 2003.
DOI : 10.1136/bmj.326.7399.1111

S. Waksman, My Life with the Microbes, Soil Science, vol.79, issue.3, pp.214-245, 1954.
DOI : 10.1097/00010694-195503000-00033

A. Schatz, E. Bugie, and S. Waksman, Streptomycin, a Substance Exhibiting Antibiotic Activity Against Gram-Positive and Gram-Negative Bacteria.*??, Experimental Biology and Medicine, vol.55, issue.1, pp.66-75, 1944.
DOI : 10.3181/00379727-55-14461

A. Schatz and S. A. Waksman, Effect of Streptomycin and Other Antibiotic Substances upon Mycobacterium tuberculosis and Related Organisms.,, Experimental Biology and Medicine, vol.57, issue.2, pp.244-252, 1944.
DOI : 10.3181/00379727-57-14769

S. Waksman, Streptomycin: background, isolation, properties, and utilization. Nobel lecture December 12th, 1952. Nobel Lectures, Physiology or Medicine, 1942.
DOI : 10.1126/science.118.3062.259

S. Waksman and H. Lechevalier, Neomycin, a New Antibiotic Active against Streptomycin-Resistant Bacteria, including Tuberculosis Organisms, Science, vol.109, issue.2830, pp.305-307, 1949.
DOI : 10.1126/science.109.2830.305

H. Umezawa, M. Ueda, and K. Maeda, Production and isolation of a new antibiotic, kanamycin, J Antibiot (Tokyo), vol.10, pp.181-189, 1957.

M. Weinstein, G. Luedemann, and E. Oden, a New Antibiotic Complex from Micromonospora, Journal of Medicinal Chemistry, vol.6, issue.4, pp.463-464, 1963.
DOI : 10.1021/jm00340a034

S. Kabins, C. Nathan, and S. Cohen, In Vitro Comparison of Netilmicin, a Semisynthetic Derivative of Sisomicin, and Four Other Aminoglycoside Antibiotics, Antimicrobial Agents and Chemotherapy, vol.10, issue.1, pp.139-145, 1976.
DOI : 10.1128/AAC.10.1.139

C. Higgins and R. Kastners, Nebramycin, a new broad-spectrum antibiotic complex

H. Kawaguchi, T. Naito, S. Nakagowa, and K. Fugijawa, BB-K8, A NEW SEMISYNTHETIC AMINOGLYCOSIDE ANTIBIOTIC, The Journal of Antibiotics, vol.25, issue.12, p.695, 1972.
DOI : 10.7164/antibiotics.25.695

W. Craig and S. Ebert, Killing and regrowth of bacteria in vitro: a review, Scand J Infect Dis, vol.74, pp.63-70, 1990.

R. Moore, P. Lietman, and C. Smith, Clinical Response to Aminoglycoside Therapy: Importance of the Ratio of Peak Concentration to Minimal Inhibitory Concentration, Journal of Infectious Diseases, vol.155, issue.1, pp.93-102, 1987.
DOI : 10.1093/infdis/155.1.93

A. Kashuba, A. Nafziger, and G. Drusano, Optimizing aminoglycosides therapy for nosocomial pneumonia caused by Gram-negative bacteria, Antimicrob Agents Chemother, vol.43, pp.623-632, 1999.

B. Isaksson, R. Mailer, and L. Nilsson, Postantibiotic effect of aminogylcosides on staphylococci, Journal of Antimicrobial Chemotherapy, vol.32, issue.2, pp.215-237, 1993.
DOI : 10.1093/jac/32.2.215

B. Isaksson, L. Nilsson, and R. Mailer, Postantibiotic effect of aminoglycosides on Gram-negative bacteria evaluated by a new method, Journal of Antimicrobial Chemotherapy, vol.22, issue.1, pp.23-33, 1988.
DOI : 10.1093/jac/22.1.23

J. Karlowsky, G. Zhanel, and R. Davidson, Postantibiotic effect in Pseudomonas aeruginosa following single and multiple aminoglycoside exposures in vitro, J Antimicrob Chemother, vol.33, issue.5, pp.937-984, 1994.

R. Chandrakanth, S. Raju, and S. Patil, Aminoglycoside-Resistance Mechanisms in Multidrug-Resistant Staphylococcus aureus Clinical Isolates, Current Microbiology, vol.36, issue.6, pp.558-62, 2008.
DOI : 10.1007/s00284-008-9123-y

M. Mingeot-leclercq and P. Tulkens, Aminoglycosides: nephrotoxicity, Antimicrob Agents Chemother, vol.43, pp.1003-1015, 1999.

R. Rea and B. Capitano, Optimizing Use of Aminoglycosides in the Critically Ill, Seminars in Respiratory and Critical Care Medicine, vol.28, issue.6, pp.596-603, 2007.
DOI : 10.1055/s-2007-996406

G. Drusano, P. Ambrose, and S. Bhavnani, Back to the future: using aminoglycosides again and how to dose them optimally, Clin Infect Dis, vol.45, pp.753-60, 2007.

G. Kahlmeter and J. Dahlager, Aminoglycoside toxicity - a review of clinical studies published between 1975 and 1982, Journal of Antimicrobial Chemotherapy, vol.13, issue.suppl A, pp.9-22, 1984.
DOI : 10.1093/jac/13.suppl_A.9

T. Ba-huy and P. , Bases pharmacocinétique de l'ototoxicité des aminosides. Comment définir le rythme optimal d'administration des aminoglycosides, pp.39-42, 1989.

G. Beaucaire, Does once daily dosing prevent nephrotoxicity in all aminoglycosides? Clinical Microbiology and Infection: the official publication of the European Society of, Clinical Microbiology and Infectious Diseases, vol.6, issue.7, pp.357-62, 2000.

R. Sandoval, J. Leiser, and B. A. Molitoris, Aminoglycoside antibiotics traffic to the Golgi complex in LLC-PK1 cells, J Am Soc Nephrol, vol.9, pp.167-174, 1998.

D. Broe, M. Paulus, G. Verpooten, and G. , Early effects of gentamicin, tobramycin, and amikacin on the human kidney, Kidney International, vol.25, issue.4, pp.643-52, 1984.
DOI : 10.1038/ki.1984.69

. Todm, C. Minozzi, and G. Beaucaire, Isepamicin in intensive care unit patients with nosocomial pneumonia: population pharmocokinetic-pharmacodynamic study, The journal of antimicrobial chemotherapy, vol.44, issue.1, pp.99-108, 1999.

J. Blaser and C. Ko?-nig, Once-daily dosing of aminoglycosides, European Journal of Clinical Microbiology & Infectious Diseases, vol.17, issue.Supplement 3, pp.1029-1067, 1995.
DOI : 10.1007/BF01590935

R. Hatala, T. Dinh, and D. Cook, Single Daily Dosing of Aminoglycosides in Immunocompromised Adults: A Systematic Review, Clinical Infectious Diseases, vol.24, issue.5, pp.810-815, 1997.
DOI : 10.1093/clinids/24.5.810

D. Broe, M. Verbist, L. Verpooten, and G. , Influence of dosage Schedule on renal accumulation of amikacin and tobramycin in man. The journal of antim chemotherapy, pp.41-48, 1991.

G. Verpooten, R. Giuliano, and L. Verbist, Once-daily dosing decrease accumulation of gentamicin and netilmicin. Clinical pharmacology and therapeutic, pp.22-29

F. Rougier, C. D. Maurin, and M. , Aminoglycoside Nephrotoxicity: Modeling, Simulation, and Control, Antimicrobial Agents and Chemotherapy, vol.47, issue.3, pp.1010-1016, 2003.
DOI : 10.1128/AAC.47.3.1010-1016.2003

URL : https://hal.archives-ouvertes.fr/hal-00427460

J. Prins, H. Buller, and E. Kuijper, Once-daily gentamicin versus once-daily netilmicin in patients with serious infections???a randomized clinical trial, Journal of Antimicrobial Chemotherapy, vol.33, issue.4, pp.823-858, 1994.
DOI : 10.1093/jac/33.4.823

M. Barza, J. Ioannidis, and J. Cappelleri, Single or multiple daily doses of aminoglycosides: a meta- analysis, BMJ, vol.312, issue.7027, pp.338-383, 1996.
DOI : 10.1136/bmj.312.7027.338

M. Ali and M. Goetz, A Meta-Analysis of the Relative Efficacy and Toxicity of Single Daily Dosing Versus Multiple Daily Dosing of Aminoglycosides, Clinical Infectious Diseases, vol.24, issue.5, pp.796-809, 1997.
DOI : 10.1093/clinids/24.5.796

M. Mavros, K. Polyzos, and P. Rafailidis, Once versus multiple daily dosing of aminoglycosides for patients with febrile neutropenia: a systematic review and meta-analysis, Journal of Antimicrobial Chemotherapy, vol.66, issue.2, pp.251-260, 2011.
DOI : 10.1093/jac/dkq451

S. Cosgrove, G. Vigliani, V. Fowler, and . Jr, Bacteremia and Endocarditis Is Nephrotoxic, Clinical Infectious Diseases, vol.48, issue.6, pp.713-734, 2009.
DOI : 10.1086/597031

K. Buchholtz, C. Larsen, and C. Hassager, Severity of Gentamicin's Nephrotoxic Effect on Patients with Infective Endocarditis: A Prospective Observational Cohort Study of 373 Patients, Clinical Infectious Diseases, vol.48, issue.1, pp.65-71, 2009.
DOI : 10.1086/594122

G. Matzke and R. Frye, Drug Administration in Patients with Renal Insufficiency Minimising Renal and Extrarenal Toxicity, Drug Safety, vol.16, issue.3, pp.205-236, 1997.
DOI : 10.2165/00002018-199716030-00005

P. Marik, Aminoglycoside volume of distribution and illness severity in critically ill septic patients, Anaesth Intensive Care, vol.21, pp.172-175, 1993.

J. Roberts and . J. Lipman, Pharmacokinetic issues for antibiotics in the critically ill patient, Critical Care Medicine, vol.37, issue.3, pp.840-51, 2009.
DOI : 10.1097/CCM.0b013e3181961bff

F. Taccone, P. Laterre, and H. Spapen, Revisiting the loading dose of amikacin for patients with severe sepsis and septic shock, Critical Care, vol.14, issue.2, p.53, 2010.
DOI : 10.1186/cc8945

E. Radigan, N. Gilchrist, and M. Miller, Management of Aminoglycosides in the Intensive Care Unit, Journal of Intensive Care Medicine, vol.25, issue.6, pp.327-369, 2010.
DOI : 10.1177/0885066610377968

G. Potel, C. Caillon, J. C. Navas, D. Kergueris, M. Batard et al., Dosage des??antibiotiques en??r??animation??: quand et??comment demander et??interpr??ter les??tests???, R??animation, vol.15, issue.3, pp.187-92, 2006.
DOI : 10.1016/j.reaurg.2006.03.011

C. Mckenzie, Antibiotic dosing in critical illness, Journal of Antimicrobial Chemotherapy, vol.66, issue.Supplement 2, pp.25-31, 2011.
DOI : 10.1093/jac/dkq516

E. Begg, M. Barclay, and S. Duffull, A suggested approach to once-daily aminoglycoside dosing., British Journal of Clinical Pharmacology, vol.56, issue.6, pp.605-614, 1995.
DOI : 10.1111/j.1365-2125.1995.tb05719.x

L. Leibovici, L. Vidal, and M. Paul, Aminoglycoside drugs in clinical practice: an evidence-based approach, Journal of Antimicrobial Chemotherapy, vol.63, issue.2, pp.246-51, 2009.
DOI : 10.1093/jac/dkn469

G. Beaucaire, C. Minozzi, and M. Tod, Clinical efficacy of IV once-daily dosing isepamicin used five or ten days, with or without initial loading dose in ICU, ICAAC, pp.39-371

G. Habib, B. Hoen, and P. Tornos, Guidelines on the prevention, and treatment of infective endocarditis: the task force on the prevention, diagnosis and treatment of infective endocarditis of the European Society of Cardiology (ESC), Eur Heart J, vol.30, pp.2369-413, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00465409

. Recommandations-de-bonne-pratique, Infections ostéoarticulaires sur matériel (prothèse,implant,ostéosynthèse)?Spilf, 2009.

. Recommandations-pour-la-pratique-clinique, Prise en charge du pied diabétique infecté ? Spilf, 2006.

. Recommandations-de-bonne-pratique, Spondylodiscites infectieuses primitives et secondaires à un geste inra discal, sans mise en place de matériel ? Spilf, 2007.

J. Zahar, C. Rioux, and E. Girou, Inappropriate prescribing of aminoglycosides: risk factors and impact of an antibiotic control team, Journal of Antimicrobial Chemotherapy, vol.58, issue.3, pp.651-657, 2006.
DOI : 10.1093/jac/dkl288

M. Paul, I. Benuri-silgiber, K. Soares-weiser, and L. Leibovici, ?? lactam monotherapy versus ?? lactam-aminoglycoside combination therapy for sepsis in immunocompetent patients: systematic review and meta-analysis of randomised trials, BMJ, vol.328, issue.7441, p.668, 2004.
DOI : 10.1136/bmj.38028.520995.63

P. Furno, G. Bucaneve, D. Favero, and A. , Monotherapy or aminoglycoside-containing combinations for empirical antibiotic treatment of febrile neutropenic patients: a meta-analysis, The Lancet Infectious Diseases, vol.2, issue.4, pp.231-273, 2002.
DOI : 10.1016/S1473-3099(02)00241-4

H. Elphick and A. Tan, Single versus combination intravenous antibiotic therapy for people with cystic fibrosis, Cochrane Database Syst Rev, issue.2, p.2007, 2005.

N. Safdar, J. Handelsman, and D. Maki, Does combination antimicrobial therapy reduce mortality in Gram-negative bacteraemia? A meta-analysis, The Lancet Infectious Diseases, vol.4, issue.8, pp.519-546, 2004.
DOI : 10.1016/S1473-3099(04)01108-9

J. Korvick, C. Bryan, B. Farber, B. Jr, . Tr et al., Prospective observational study of Klebsiella bacteremia in 230 patients: outcome for antibiotic combinations versus monotherapy., Antimicrobial Agents and Chemotherapy, vol.36, issue.12, pp.2639-2683, 1992.
DOI : 10.1128/AAC.36.12.2639

J. Graham and J. Gould, Role of aminoglycosides in the treatment of bacterial endocarditis, Journal of Antimicrobial Chemotherapy, vol.49, issue.3
DOI : 10.1093/jac/49.3.437

J. Chastre and J. Fagon, Ventilator-associated Pneumonia, American Journal of Respiratory and Critical Care Medicine, vol.165, issue.7, pp.867-903, 2002.
DOI : 10.1164/ajrccm.165.7.2105078

H. Dupont, C. Carbon, and J. Carlet, Monotherapy with a Broad-Spectrum Beta-Lactam Is as Effective as Its Combination with an Aminoglycoside in Treatment of Severe Generalized Peritonitis: a Multicenter Randomized Controlled Trial, Antimicrobial Agents and Chemotherapy, vol.44, issue.8, pp.2028-2061, 2000.
DOI : 10.1128/AAC.44.8.2028-2033.2000

J. Cardinaud, Rotation and restricted use of antibiotics in a medical intensive care unit: impact on the incidence of ventilator-associated pneumonia caused by antibiotic-resistant gram-negative bacteria, Am J Respir Crit Care Med, vol.162, pp.837-843, 2000.

K. Laczika, T. Staudinger, U. Hollenstein, E. Presterl, G. Locker et al., Renal tolerability of four different once-daily dose regimen of netilmicin in critical care patients, Wien Klin Wochenschr, vol.109, pp.840-844, 1997.

M. Rybak, B. Abate, and S. Kang, Prospective evaluation of the effect of an aminoglycoside dosing regimen on rates of observed nephrotoxicity and ototoxicity

N. Fukuoka and M. Aibki, , does not achieve desired serum concentration in critically ill patients with lowered creatinine clearance, Journal of Clinical Pharmacy and Therapeutics, vol.50, issue.5, pp.521-527, 2008.
DOI : 10.1111/j.1365-2710.2008.00947.x

J. Barletta, S. Johnson, D. Nix, L. Nix, and B. Erstard, Population Pharmacokinetics of Aminoglycosides in Critically Ill Trauma Patients on Once-Daily Regimens, The Journal of Trauma: Injury, Infection, and Critical Care, vol.49, issue.5, pp.869-872, 2000.
DOI : 10.1097/00005373-200011000-00013

T. Gilbert, S. Jacobs, A. Quaddoura, B. Ferrara, and R. Phillips, Deafness and prolonged neuromuscular blockade following single-dose peritoneal neomycin irrigation, Canadian Journal of Anaesthesia, vol.54, issue.6, pp.568-570710, 1957.
DOI : 10.1007/BF03012710

W. Warner and E. Sanders, Neuromuscular Blockade Associated With Gentamicin Therapy, JAMA: The Journal of the American Medical Association, vol.215, issue.7, pp.1153-1154, 1971.
DOI : 10.1001/jama.1971.03180200075022

P. Waterman and R. Smith, Tobramycin-Curare Interaction, Anesthesia & Analgesia, vol.56, issue.4, pp.587-588, 1977.
DOI : 10.1213/00000539-197707000-00034

J. Wong and G. Brown, Does once-daily dosing of aminoglycosides affect neuromuscular function?, Journal of Clinical Pharmacy and Therapeutics, vol.7, issue.6, pp.407-411, 1996.
DOI : 10.1111/j.1365-2710.1996.tb00039.x

C. Sawyers, R. Moore, and S. Lerner, A model for predicting nephrotoxicity in patients treated with aminoglycosides. The Journal of infectious diseases, pp.1062-1070, 1986.

R. Moore, C. Smith, and J. Lipsky, Risk factors for nephrotoxicity in patients treated with aminoglycosides. Annals of internal medicine, pp.352-359, 1984.

D. Leehey, B. Braun, and D. Tholl, Can pharmacokinetic dosing decrease nephrotoxicity associated with aminoglycoside therapy, Journal of the American Society of Nephrology : JASN, vol.4, issue.1, pp.99-108, 1993.

D. Streetman, A. Nafziger, and C. Destache, Individualized Pharmacokinetic Monitoring Results in Less Aminoglycoside-Associated Nephrotoxicity and Fewer Associated Costs, Pharmacotherapy: Official Journal of the American College of Clinical Pharmacy, vol.13, issue.4, pp.443-51, 2001.
DOI : 10.1016/S0140-6736(78)92825-8

W. Sweileh, Gender differences in aminoglycoside induced nephrotoxicity: a prospective, hospital-based study. Current clinical pharmacology, pp.229-261, 2009.

J. Oliveira, C. Silva, and C. Barbieri, Prevalence and Risk Factors for Aminoglycoside Nephrotoxicity in Intensive Care Units, Antimicrobial Agents and Chemotherapy, vol.53, issue.7, pp.2887-91, 2009.
DOI : 10.1128/AAC.01430-08

A. Baciewicz, D. Sokos, and R. Cowan, Aminoglycoside-associated nephrotoxicity in the elderly. The Annals of pharmacotherapy, pp.182-188, 2003.

H. Hampel, G. Bynum, and E. Zamora, Risk factors for the development of renal dysfunction in hospitalized patients with cirrhosis. The American journal of gastroenterology, pp.2206-2216, 2001.

J. Bertino, J. Booker, L. Franck, and P. , Incidence of and Significant Risk Factors for Aminoglycoside-Associated Nephrotoxicity in Patients Dosed by Using Individualized Pharmacokinetic Monitoring, Journal of Infectious Diseases, vol.167, issue.1, pp.173-182, 1993.
DOI : 10.1093/infdis/167.1.173

J. Cortes, G. Gamba, and A. Contreras, Amikacin nephrotoxicity in patients with chronic liver disease Revista de investigacion clinica, Nutricion, vol.42, issue.2, pp.93-101, 1990.

J. Lopez-novoa, Y. Quiros, and L. Vicente, New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view, Kidney International, vol.79, issue.1, pp.33-45, 2011.
DOI : 10.1038/ki.2010.337

R. Zager and . Endotoxemia, Endotoxemia, Renal Hypoperfusion, and Fever: Interactive Risk Factors for Aminoglycoside and Sepsis-Associated Acute Renal Failure, American Journal of Kidney Diseases, vol.20, issue.3, pp.223-253, 1992.
DOI : 10.1016/S0272-6386(12)80694-9

A. Contreras, M. Ramirez, and L. Cueva, Low serum albumin and the increased risk of amikacin nephrotoxicity Revista de investigacion clinica, Nutricion, vol.46, issue.1, pp.37-43, 1994.

J. Prins, H. Buller, and E. Kuijper, Once versus thrice daily gentamicin in patients with serious infections, The Lancet, vol.341, issue.8841, pp.335-344, 1993.
DOI : 10.1016/0140-6736(93)90137-6

G. Drusano and A. Louie, Optimization of Aminoglycoside Therapy, Antimicrobial Agents and Chemotherapy, vol.55, issue.6, pp.2528-2559, 2011.
DOI : 10.1128/AAC.01314-10

J. Prins, G. Weverling, and K. De-block, Validation and nephrotoxicity of a simplified once-daily aminoglycoside dosing schedule and guidelines for monitoring therapy, Antimicrobial agents and chemotherapy, vol.40, issue.11, pp.2494-2503, 1996.

N. Pannu and M. Nadim, An overview of drug-induced acute kidney injury, Critical Care Medicine, vol.36, issue.Suppl, pp.216-239, 2008.
DOI : 10.1097/CCM.0b013e318168e375

J. Prins, G. Weverling, and R. Van-ketel, Circadian variations in serum levels and the renal toxicity of aminoglycosides in patients, Clinical Pharmacology & Therapeutics, vol.158, issue.1, pp.106-117, 1997.
DOI : 10.1016/S0009-9236(97)90156-9

W. Munckhof, M. Grayson, and J. Turnidge, A meta-analysis of studies on the safety and efficacy of aminoglycosides given either once daily or as divided doses, Journal of Antimicrobial Chemotherapy, vol.37, issue.4, pp.645-63, 1996.
DOI : 10.1093/jac/37.4.645

D. Lawson, W. Tilstone, and J. Gray, Effect of Furosemide on the Pharmacokinetics of Gentamicin in Patients, The Journal of Clinical Pharmacology, vol.2, issue.5, pp.5-6254, 1982.
DOI : 10.1002/j.1552-4604.1982.tb02670.x

C. Smith and P. Lietman, Effect of furosemide on aminoglycoside-induced nephrotoxicity and auditory toxicity in humans., Antimicrobial Agents and Chemotherapy, vol.23, issue.1, pp.133-140, 1983.
DOI : 10.1128/AAC.23.1.133

S. Uchino, An assessment of the RIFLE criteria for acute renal failure in hospitalized patients*, Critical Care Medicine, vol.34, issue.7, pp.1913-1920, 2006.
DOI : 10.1097/01.CCM.0000224227.70642.4F

R. Bellomo, C. Ronco, J. Kellum, R. Mehta, and P. Palevsky, Acute renal failure definition, outcome measures, animal models, fluid therapy and information technology needs: the second international consensus conference of the acute dialysis quality initiative (ADQI) group, Critical Care, vol.8, issue.4, pp.204-212, 2004.
DOI : 10.1186/cc2872

L. Gall and J. , A new simplified acute physiology score (SAPS II) based on a

. European, North American multicenter study, JAMA, vol.270, pp.2957-2963, 1993.

J. Vincente, R. Moreno, J. Takala, S. Willatts, D. Mendoça et al., Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units, Critical Care Medicine, vol.26, issue.11, pp.1793-800, 1998.
DOI : 10.1097/00003246-199811000-00016

B. Boucher, B. Coffey, and D. Kuhl, Algorithm for assessing renal dysfunction risk in critically ill trauma patients receiving aminoglycosides, The American Journal of Surgery, vol.160, issue.5, pp.473-80, 1990.
DOI : 10.1016/S0002-9610(05)81007-4

J. Labaune, Pharmacocinétique : Principes fondamentaux, 1984.

S. Bhat, S. Fujitani, and B. Potoski, Pseudomonas aeruginosa infections in the Intensive Care Unit: can the adequacy of empirical beta-lactam antibiotic therapy be improved? International journal of antimicrobial agents, pp.458-62, 2007.

J. Beardsley, J. Williamson, and J. Johnson, Using Local Microbiologic Data To Develop Institution-Specific Guidelines for the Treatment of Hospital-Acquired Pneumonia, Chest, vol.130, issue.3
DOI : 10.1378/chest.130.3.787

D. Commandeur, S. Eyrieux, L. Noël, and A. , Monitorage des aminosides en r??animation, M??decine et Maladies Infectieuses, vol.40, issue.2, pp.94-99, 2012.
DOI : 10.1016/j.medmal.2009.08.011

G. Beaucaire, O. Leroy, C. Beuscart, P. Karp, C. Chidiac et al., Clinical and bacteriological efficacy, and practical aspects of amikacin given once daily for severe infections, Journal of Antimicrobial Chemotherapy, vol.27, issue.suppl C, pp.91-103, 1991.
DOI : 10.1093/jac/27.suppl_C.91

F. Scaglione and L. Paraboni, Pharmacokinetics/pharmacodynamics of antibacterials in the Intensive Care Unit: setting appropriate dosing regimens, International Journal of Antimicrobial Agents, vol.32, issue.4, pp.294-301, 2008.
DOI : 10.1016/j.ijantimicag.2008.03.015

M. Hansen, L. Christrup, J. Jarlov, J. Kampmann, and J. Bonde, Gentamicin dosing in critically ill patients, Acta Anaesthesiologica Scandinavica, vol.12, issue.6, pp.734-774, 2001.
DOI : 10.1086/313692