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Master Thesis

Efficacité du sommeil et sévérité des symptômes dans la maladie de Crohn et le syndrome de l’intestin irritable : résultats d'une étude observationnelle

Abstract : Crohn's disease (CD) and Irritable Bowel Syndrome (IBS) are common digestive diseases responsible for transit disorders and abdominal pain. Their pathophysiology is unclear; a better understanding of the causes of these diseases could provide an optimized care. Among the environmental factors suspected to be involved, the role of sleep disorders has recently been put forward. Sleep is indeed involved in the regulation of inflammation, healing process and digestion. We conducted an observational cross study, analytical, monocentric, to study the association between sleep efficiency and severity of symptoms in IBS and CD, on CD outpatients coming in day hospitalization or consulting IBS. Their sleep was recorded during one week through wrist actimeters. The clinical activity of their disease, their quality of life, the quality of their sleep and their psychological profiles were also assessed by questionnaires at baseline. Thirty-four patients with CD, including 20 in clinical remission and 14 with active disease and 15 IBS patients were included. Sleep efficiency was lower among patients with active CD compared with patients in remission. There was no correlation between efficiency and severity of symptoms among patients with IBS. Patients with active CD were more frequently characterized as "poor sleepers" and frequently suffered from excessive daytime sleepiness without an excess risk of obstructive sleep apnea. These results were not found in the group of patients with IBS. The subjective assessment of sleep quality was lower in patients with IBS compared to CD patients. Sleep efficiency is reduced in our MC active population compared with patients in remission, suggesting that sleep disturbances may affect the natural history of this disease. Randomized clinical trials are needed to evaluate the impact of sleep care on the natural history of the disease.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01224733
Contributor : Bu Carreire Université de Bordeaux <>
Submitted on : Thursday, November 5, 2015 - 9:11:51 AM
Last modification on : Wednesday, August 23, 2017 - 4:29:03 PM
Long-term archiving on: : Friday, April 28, 2017 - 4:42:56 AM

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Thomas Bazin. Efficacité du sommeil et sévérité des symptômes dans la maladie de Crohn et le syndrome de l’intestin irritable : résultats d'une étude observationnelle. Médecine humaine et pathologie. 2015. ⟨dumas-01224733⟩

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