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Master Thesis

Étude descriptive et analytique de la cohorte de patients greffés cardiaques au C.H.U. de Bordeaux

Abstract : Introduction. Heart transplantation is the reference treatment for end-stage heart failure. Current goal is to select patients with a high risk of death during expectation of graft but who are the more likely to survive after transplantation. Thus, we performed a study to describe ways and results of heart transplantation programme in our center, assess mortality and its risk factors and validate INTERMACS classification and INTERMACS score in our patients. Method. We performed a retrospective monocentric cohort study. All patients undergoing a single organ heart transplantation were included. We recorded features in recipients at time of transplantation and their outcomes (death, complications). We compute INTERMACS classification and INTERMACS score performance in our cohort. Results. From 2004 to 2014, 114 patients underwent a single heart transplant in our hospital. Twenty-one patients were transplanted on level 1 emergency priority list. All of them were hospitalized before transplantation (38% underwent mechanical ventilation and 42% underwent hemofiltration). Global survival at month one was 90% and it was 72% at one year. Patients who underwent an emergency transplantation had higher mortality (one year survival 57%). Factors associated with one month mortality were recipients features (weight, congenital heart failure etiology, bilirubin), transplantation context (use of vaso active drugs, mechanical ventilation, intensive care unit before transplant), posttransplantation complications. INTERMACS classification and IMPACT score were correlated with mortality in our cohort with OR = 0,67 (IC95 (0,48-0,92) p = 0,02) and OR = 1,13 (IC95 (1,03-1,25) p = 0,01), respectively. Conclusion. Survival after heart transplantation is close to national results, and INTERMACS classification and IMPACT score seem to have consistent results in our cohort. Pre-transplantation critical status is a major risk factor for transplantation success.
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Master Thesis
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Contributor : Bu Carreire Université de Bordeaux <>
Submitted on : Friday, November 20, 2015 - 11:33:35 AM
Last modification on : Wednesday, August 23, 2017 - 4:40:47 PM
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  • HAL Id : dumas-01231434, version 1



Sabine Urdampilleta-Inda. Étude descriptive et analytique de la cohorte de patients greffés cardiaques au C.H.U. de Bordeaux. Médecine humaine et pathologie. 2015. ⟨dumas-01231434⟩



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