Étude du baclofène dans les compulsions alimentaires résistantes : efficacité, tolérance et modalités de prescription

Abstract : Introduction: Obesity and eating disorders appear to share common neurobiological mechanisms with addictions for which the use of baclofen for a few years has shown some promising results. Aims: Main objective is to assess efficiency of baclofen in Compulsive Eating Disorders (CED) for patients in therapeutic stalemate. Secondary objectives are to identify the predictive clinical and psychopathological criteria of therapeutic response, to assess the tolerance and to characterize terms of baclofen prescription. Method: It’s a compassionate prospective uncontrolled study evaluating the effectiveness of a baclofen based treatment on a group of 27 patients with a CED characteristic that has evolved for a period of at least 5 years. An assessment of the evolution of various parameters was carried out: weight, intensity and frequency of binge eating, craving, specific psychopathological features and biological tolerance. Results: Over the six months of treatment, 56% of patients lost weight without restrictive instructions. In addition, regardless of any weight variation, all types of eating disorders decreased parallel to the reduction of craving. It appears that a predominance of night eating disorder doesn’t constitute a favored indication for a baclofen treatment. Despite an average daily dose of 150 mg of baclofen, side effects are mainly mild and transient. Conclusion: This study shows that baclofen seems to act on the patients control capacities against their disorders. It allowed us to precise the requirement of a personalized prescription.
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Master Thesis
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Flore-Anne Mayne. Étude du baclofène dans les compulsions alimentaires résistantes : efficacité, tolérance et modalités de prescription. Sciences pharmaceutiques. 2014. ⟨dumas-01674555⟩

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