. De, apparition de la forme maligne est brusque et exubérante ; souvent associée à un prurit important. 229 3.2.2. Principales différences entre les divers Acanthosis Nigricans Les manifestations pathologiques primaires des formes bénignes et malignes de l'Acanthosis Nigricans sont identiques, caractérisées par une hyperkératose, une acanthose, une augmentation de la pigmentation cutanée et une hyperplasie papillomateuse de l'épiderme, p.230

. La-différenciation-de-l, Acanthosis Nigricans paranéoplasique de ses homologues repose sur le diagnostic de l'étiologie sous-jacente, p.231

L. Ainsi and . Diagnostic, Acanthosis Nigricans malin ne peut être établit qu'à partir de manifestations pathologiques et du diagnostic d'une néoplasie interne, p.235

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