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Master Thesis

Impact de l’alimentation sur les troubles dépressifs de l’adulte et leur prise en charge : synthèse de la littérature

Abstract : Depression is a common psychiatric disorder that heavily impacts the quality of life of patients and the overall burden of health-related costs. Its physiopathological mechanisms are not yet fully understood, and several hypotheses have been proposed. Current therapeutic management includes psychotherapies, drug treatments and brain stimulation techniques. Lifestyle elements such as diet and exercise are important factors in the prevention and management of many chronic diseases including metabolic diseases, cardiovascular, neurodegenerative and cancer. Recently, knowledge on the microbiota-intestine-brain axis has come to provide new insights into the link between neuropsychiatric pathologies and diet. This is essential to provide the necessary nutrients for proper brain function. Studies tend to show a negative impact of certain nutritional deficiencies (vitamins B, C, D, omega-3 fatty acids, zinc, magnesium, iron, tryptophan, SAMe) and a positive impact of their supplementation on depressive disorders. A significant association is found between the quality of the diet and the reduction of the risk of depression, and in particular with the observance of a Mediterranean type diet. Finally, recent prospective clinical trials evaluating the effectiveness of dietary interventions in the management of depression provide encouraging results for further research and to begin to take these new data into account in clinical practice.
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Master Thesis
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Contributor : Jean-Hugues Morneau <>
Submitted on : Monday, June 17, 2019 - 12:03:11 PM
Last modification on : Tuesday, May 11, 2021 - 11:36:24 AM


  • HAL Id : dumas-02157713, version 1


Marion Bugaud. Impact de l’alimentation sur les troubles dépressifs de l’adulte et leur prise en charge : synthèse de la littérature. Médecine humaine et pathologie. 2019. ⟨dumas-02157713⟩



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