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Master Thesis

Aspects cliniques, biologiques, thérapeutiques et retentissement électrocardiographique du paludisme à Plasmodium falciparum. Étude rétrospective à propos de 104 cas consécutifs traités au Pôle de Santé Unique du Camp Kosseï à N'Djamena

Abstract : Plasmodium falciparum malaria remains one of the leading causes of morbidity and mortality in Africa. Currently gold standard treatment for uncomplicated malaria disease is an Artemisinin-based Combination Therapies (ACT). In Chad, Camp Kosseï’s “Pôle de Santé Unique” (PSU) in N'Djamena supports Barkhane Operation’s French armed forces. Medical assistance for local population is also provided. According French Military Medical Society guidelines in operations, physicians must realize an electrocardiogram (ECG) when using Eurartésim® (ACT), because of risk of QT prolongation and Torsades de pointes. In this context, we realized a retrospective study, evaluating epidemiologic, clinical and biological data, about 104 consecutive patients, with electrocardiographic data and impact of ACT on repolarization, between August 31st and November 3rd, 2017. All patients had fever (38,4°C), asthenia, and main symptoms were headache and arthromyalgia (58%). No significant difference was noted after treatment concerning biological data (especially kaliemia: 3.81 versus 3.91 mmol / L, p = 0.154). There was no significant increase of QTc (415.8 versus 421.4 ms, p = 0.89) with ACT treatment and no adverse events. This is in favour of a good rhythmic tolerance of Eurartésim® and it should be proposed not to realize systematic ECG for the French soldiers in external operation treated with ACT.
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https://dumas.ccsd.cnrs.fr/dumas-02361277
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Submitted on : Wednesday, November 13, 2019 - 12:04:17 PM
Last modification on : Friday, October 23, 2020 - 4:58:54 PM
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Dorian Cellarier. Aspects cliniques, biologiques, thérapeutiques et retentissement électrocardiographique du paludisme à Plasmodium falciparum. Étude rétrospective à propos de 104 cas consécutifs traités au Pôle de Santé Unique du Camp Kosseï à N'Djamena. Sciences du Vivant [q-bio]. 2019. ⟨dumas-02361277⟩

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