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Master Thesis

La Relaxine : état des lieux et applications au domaine orthodontique

Abstract : Human relaxin-2, more simply referred to as relaxin, is a polypeptide hormone produced in the male and female sexual organs. It acts on its receptors, the RXFPs, whose localization within the human body is ubiquitous and whose activation induces a set of intracellular reactions resulting in the triggering of numerous signaling pathways. Relaxin has, inter alia, vasodilator, anti-apoptotic, anti-fibrotic, angiogenic and anti-inflammatory effects. At the orthodontic level, it has been tested several times in the acceleration of treatments or the reduction of relapse but these researches did not lead to any marketing or concrete protocol of use. Research is now directed more towards the ability it would have to accelerate healing and modulate the metabolism of soft and skeletal tissues. These properties would allow relaxin to greatly facilitate the care of patients clefted or whose therapeutic possibilities are greatly reduced by the end of their growth.
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Master Thesis
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Submitted on : Wednesday, April 7, 2021 - 11:17:43 AM
Last modification on : Tuesday, October 19, 2021 - 10:35:23 PM
Long-term archiving on: : Thursday, July 8, 2021 - 7:04:43 PM


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  • HAL Id : dumas-03191509, version 1


Pierre Vieillard. La Relaxine : état des lieux et applications au domaine orthodontique. Chirurgie. 2020. ⟨dumas-03191509⟩



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