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Master Thesis

Aspect et visibilité des cancers du sein en tomosynthèse en fonction de leurs caractéristiques moléculaires

Abstract : Objective: to describe BI-RADS features and evaluate conspicuity of breast cancer on DBT according to their molecular profile. Materials and method: institutional review board with waiver of informed consent was obtained for this retrospective study. Consecutive Patients with histologically proven breast cancers who underwent digital breast tomosynthesis (DBT) and digital mammography (DM) at the time of diagnosis where included. Morphological features and conspicuity of cancers on DM and DBT were evaluated in consensus by two breast radiologists. Imaging features of luminal, triple negative (TN) and HER-2+ cancers were compared using Fischer exact test. Conspicuity of cancers was compared between DBT and DM using Wilcoxon matched rank test and between each molecular type using Mann Whitney U test. Results: one hundred eleven consecutive patients were included. On DBT, TN cancers more frequently presented as masses with microlobulated margins (P=0.02) while HER-2+ cancers were more often associated with microcalcifications (P=0.04). Cancers with low Ki67 (P=.015), less aggressive tumors (P=.005), positive ER (P=.005), positive PR (P=.005) or negative HER-2 (P=.024), and luminal molecular profiles (P=0.012) demonstrated better conspicuity on DBT than on DM while no difference was observed between the two techniques for TN (P=.73) and HER-2+ (P=.79) tumors. Conclusion: breast cancers may demonstrate specific features on DBT according to their molecular characteristics. In comparison with DM, DBT improves conspicuity of luminal subtypes cancers and tumors demonstrating less aggressive features on pathology.
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https://dumas.ccsd.cnrs.fr/dumas-03263830
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Submitted on : Thursday, June 17, 2021 - 3:53:40 PM
Last modification on : Friday, July 9, 2021 - 3:48:02 AM
Long-term archiving on: : Saturday, September 18, 2021 - 6:48:18 PM

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  • HAL Id : dumas-03263830, version 1

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Léa Manse. Aspect et visibilité des cancers du sein en tomosynthèse en fonction de leurs caractéristiques moléculaires. Sciences du Vivant [q-bio]. 2021. ⟨dumas-03263830⟩

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