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Master Thesis

Le trouble du déficit de l’attention avec hyperactivité (TDAH) et la maladie atopique sont-ils indépendants ? Revue systématique de la littérature et méta-analyses

Abstract : Attention-deficit hyperactivity disorder (ADHD) and atopic disease are two major public health issues, between which several studies have reported a significant association. The objective of this study was to systematically identify studies on the association between ADHD and clinical atopic disease in the international paediatric population. Then, quantify the intensity of this link in order to better understand the underlying mechanisms and its possible consequences on the diagnostic and therapeutic approach. We conducted a systematic review by extracting references from the PubMed and Scopus electronic databases. The included studies looked at clinical atopy and ADHD in the paediatric population. Several meta-analyses were performed using the reported odds-ratios. Factors that may influence this possible link and the impact of therapeutics were also collected. We selected 85 studies from which only ten case-control studies could be meta-analysed. Meta-analyses showed significant associations between children with ADHD and asthma (OR: 1.37 CI: 95%: 1.20-1.50, I2: 67.6%), atopic dermatitis (OR at 1.45 CI: 95%: 1.27-1.67, I2:60%), allergic rhinitis (OR:1.62 (1.64-1.88) I2:73.8%) and allergic conjunctivitis (1.64 CI:95%: 1.57-1.72, I2:0%) compared to the control group. However, the high statistical heterogeneity reflects the variability of the criteria for defining the different pathologies. In conclusion, this systematic review of the literature with meta-analyses found a significant association between ADHD and atopic disease.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-03371419
Contributor : Bibliothèque Universitaire de Médecine Nice Connect in order to contact the contributor
Submitted on : Friday, October 8, 2021 - 3:52:27 PM
Last modification on : Thursday, October 21, 2021 - 4:14:29 AM

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  • HAL Id : dumas-03371419, version 1

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Jean-Marc Gilardoni. Le trouble du déficit de l’attention avec hyperactivité (TDAH) et la maladie atopique sont-ils indépendants ? Revue systématique de la littérature et méta-analyses. Médecine humaine et pathologie. 2021. ⟨dumas-03371419⟩

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