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Master Thesis

Étude transversale observationnelle des manifestations cutanées survenues sous biothérapies dans une cohorte de 102 patients suivis en hôpital de jour de Rhumatologie au CHU de Grenoble

Abstract : Introduction: The anti-TNF are widely used for treatment of autoimmune diseases and skin reactions are now better known thanks to their increasing use. By cons, new biological therapies have been developed in rheumatoid arthritis with cutaneous side effects remain to be defined. Methods: One hundred two patients treated with biologic therapies in rheumatology were included in an original study of prevalence and retrospective, monocentric and underwent an examination and a complete skin exam. A collection of all cutaneous manifestations was made. Results: Over half of patients had no regular dermatological follow-up despite the recommendations of rheumatologists. The prevalence of skin cancers was 4.9%. The identified risk factors are advanced age and phototype clear. The number of biotherapy and the total duration of treatment does not seem to interfere in our study. The possibility of an excess risk of skin cancer can not be evaluated with the new biotherapeutics. We have highlighted a significant number of skin infections, including herpes virus, as biotherapy. The majority of these infections occurred significantly in patients followed for rheumatoid arthritis (p = 0.04) in infliximab (p = 0.04) and treated with methotrexate for a long time (p = 0.02). Conclusion: This study confirms the importance of education and monitoring dermatological patients treated with biologics, especially with the development of new immunomodulatory agents whose cutaneous side effects are still poorly understood.
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Master Thesis
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Submitted on : Monday, April 16, 2012 - 11:35:11 AM
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Alexandrine Cozzi. Étude transversale observationnelle des manifestations cutanées survenues sous biothérapies dans une cohorte de 102 patients suivis en hôpital de jour de Rhumatologie au CHU de Grenoble. Médecine humaine et pathologie. 2012. ⟨dumas-00687986⟩

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