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Master Thesis

Les médicaments dopaminergiques : de la maladie de Parkinson aux traitements des addictions

Abstract : Degeneration of the dopaminergic system in Parkinson's disease and longstanding exposure to dopaminergic drugs may cause reward system dysfunction. This may manifest as addiction to dopaminergic drugs and behavorial disturbances associated with the impulse control system. Behavioral changes in Parkinson's disease are complex and their pathophysiology is not yet fully understood. The dopaminergic system seems to play a major role and most of the behavioral disorders in Parkinson's disease can be classified into either hypodopaminergic if related to the disease itself or hyperdopaminergic if related to dopaminergic treatment. Activation of the mesocorticolimbic dopaminergic system by drugs of abuse plays a key role in the development and maintenance of addictive behavior. Chronic exposure to drugs of abuse results in neurobiological dysfunctions and neuropsychiatric disorders. The classification of mood disorders based on the "dopaminergic status" of each patient can be applied to addictions. The use of pharmacological agents has become a standard approach to attempt to ameliorate aspects of drug addiction in combination with social and behavioral treatment. While pharmacotherapy may be an effective approach to the treatment of drug addiction for individuals, the prevalence of this disorder remains unacceptably high. The characterization of the central dopaminergic sensitivity could be a promising approach for the development of novel treatments for addictions. Such as the exploitation of cerebral stimulation or imaging techniques. Those one provide new insights on the role of dopamine in drug abuse and addiction in the human brain.
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Master Thesis
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Submitted on : Thursday, August 16, 2012 - 12:12:49 PM
Last modification on : Tuesday, May 11, 2021 - 11:36:16 AM
Long-term archiving on: : Saturday, November 17, 2012 - 2:21:40 AM


  • HAL Id : dumas-00724000, version 1
  • PPN : 163511152


Cécile Jeane Chevallier. Les médicaments dopaminergiques : de la maladie de Parkinson aux traitements des addictions. Sciences pharmaceutiques. 2012. ⟨dumas-00724000⟩



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