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Master Thesis

Association entre lymphopénie et mortalité chez les sujets âgés admis en unité de médecine aigüe gériatrique

Abstract : Introduction: Lymphocytopenia of elderly patients has been studied as a mortality prognostic factor with different outcomes. It has been little studied in acute geriatric care situation. Methods : All the patients admitted in the Chatin acute geriatric unit, Grenoble Universitary Hospital, France, from May to October 2011, were retrospectively included, with a biological assessment ( Lymphocytemia, Albuminemia and C-Reactive Protein) and a clinical assessment (Infection suspicion, Charlson's score, ADL Day-15). Exclusion criteria were: malignant hemopathy, repeted admission. Results : Finally, 239 elderly patients were evaluated. Lymphocytopenia under 1.1 G/l was a prognostic factor for in-hospital mortality : OR = 3,44 (1,55 - 8,10), p=0.003. The prevalence of lymphocytopenia was 39% and the mortality rate was 13%. Denutrition with albuminemia under 30g/l was also a prognostic factor for in-hospital mortality : OR= 4,90 (2,17-11,86), p<0.001. Lymphocytopenia and hypoalbuminemia were significatively correlated but were independantly predictive of mortality with the multivariate analysis model. Conclusion : Lymphocytemia is an easy accessible immunity factor in daily clinical practice and should be taken in account for the global geriatric assessment of elderly patients in acute situation, as a global frailty factor, predictive of mortality, and as a reflection of both immunosenescence, denutrition and polypathology.
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Master Thesis
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Submitted on : Monday, October 22, 2012 - 2:26:42 PM
Last modification on : Tuesday, May 11, 2021 - 11:36:17 AM


  • HAL Id : dumas-00744165, version 1
  • PPN : 164902252


Patrice Lombrail. Association entre lymphopénie et mortalité chez les sujets âgés admis en unité de médecine aigüe gériatrique. Médecine humaine et pathologie. 2012. ⟨dumas-00744165⟩



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