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Master Thesis

Variation de sensibilité aux traitements psychotropes et origine génétique : à propos de huit cas de patients asiatiques

Abstract : Further to my recurring report, within various services of hospitalization in adult psychiatry, variations of sensibility in treatments at the patients of Asian origin; I wished to be interested in the problem of the specificities of this population concerning the answer to the psychotropic treatments through a review of the literature, confronted secondly with my clinical experiment with the patients. In the first part I describe therefore the contribution of pharmacogenetics data in understanding individual variability in response to treatment and psychotropic drugs in general along ethnic comparisons, before specifying the influence of non-genetic factors in interindividual variations pharmacological response. Subsequently I relate the clinical course of eight patients of Asian origin, highlighting changes in response to treatment with psychotropic partial agreement with the data from the literature. Observation which constitutes the starting point of my following discussion and which comes to underline the interest of pharmacogenetic while reinforcing the need for remaining careful in the generalization of the results of the studies of pharmacogenetic to the whole of a population. I concluded my work by underlining the interest, the current limits, the ethical hopes and challenges of pharmacogenetic and its development in the years to come for the clinical practice from psychiatry, like instrument of assistance to the regulation among others.
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Master Thesis
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Submitted on : Thursday, October 25, 2012 - 11:29:53 AM
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  • HAL Id : dumas-00745296, version 1


Laetitia Duval. Variation de sensibilité aux traitements psychotropes et origine génétique : à propos de huit cas de patients asiatiques. Médecine humaine et pathologie. 2012. ⟨dumas-00745296⟩



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