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Master Thesis

Apports des examens immunobiologiques dans les surdités auto-immunes

Abstract : We expose the pathogenic basis of autoimmune diseases and the histopathological features of the endolymphatic system and the stria vascularis. They play an important role in the immune system of the inner ear and in the experimental autoimmune inner ear diseases. Some of them show histological and/or electrophysiological changes as in the known human autoimmune diseases. Ménière's disease, sudden deafness, rapidly progressive sensorineural hearing loss are generally idiopathic. They are frequently associated with dysimmune biological tests or a good evolution under steroïds and/or immunosuppressive drugs. These findings suggest an autoimmune etiology. We realized a prospective study on 17 cases of Meniere's disease, 12 cases of sudden deafness and 16 cases of rapidly progressive sensorineural hearing loss. All the patients had an immunological screening which often showed a non specific inflammatory syndrome and systemic antibodies. The lymphoblastic transformation tests against a pool of inner ear antigens and the indirect immunofluorescent tests against human cochlea sections were positive in the same proportion than the results of the literature. ln these cases, we found a better audiological response under corticoïds. These results have to be confirmed by studies on a larger number of patients and by specifying the sensibility and the specificity of the different tests.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-00781741
Contributor : Jean-Hugues Morneau <>
Submitted on : Monday, January 28, 2013 - 11:51:04 AM
Last modification on : Tuesday, May 11, 2021 - 11:36:17 AM
Long-term archiving on: : Saturday, April 1, 2017 - 11:32:42 AM

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  • HAL Id : dumas-00781741, version 1

Citation

Jean-Michel Lejeune. Apports des examens immunobiologiques dans les surdités auto-immunes. Médecine humaine et pathologie. 1989. ⟨dumas-00781741⟩

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