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Master Thesis

Immunothérapie anti-tumorale active par vecteur bactérien vivant attenué‎ : mise au point de l'approche vaccinale "killed but metabolically active"

Abstract : Recently, active immunotherapy (vaccine) was successfully used as a secondary treatment of hormone-independent prostate cancer on human (sipuleucel-T, Provenge®). Development of specific cellular immunity needs, in a first hand, antigen transfer in an antigen presenting cell (APC). In another hand, activation of APC is a necessary step to generate a T-cytotoxic response. TheREx laboratory has developed an innovative and effective approach to subcutaneously inject the antigen directly into APC with a live-attenuated bacterial vector. We observed a production of specific CD8+ T lymphocytes against tumor-antigen, in response to this treatment.People affected by cancer are frequently vulnerable. Thus, it seems complicated to use a live-attenuated bacterial vector. We have developed a new bacterial-vector, called KBMA vaccine (Killed But Metabolically Active), based on the same antigen injection mechanism through the type III secretion system of Pseudomonas aeruginosa. This new concept gives KBMA bacteria able to produce antigen and to transfer it into APC without the ability to replicate into the host. Therefore, the secondary effects of such treatment are reduced. This work demonstrates the efficiency of this new bacterial vector for cancer immunotherapy.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-00822794
Contributor : Jean-Hugues Morneau <>
Submitted on : Wednesday, May 15, 2013 - 2:09:54 PM
Last modification on : Tuesday, May 11, 2021 - 11:36:16 AM
Long-term archiving on: : Tuesday, April 4, 2017 - 7:13:11 AM

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  • HAL Id : dumas-00822794, version 1

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Xavier Chauchet. Immunothérapie anti-tumorale active par vecteur bactérien vivant attenué‎ : mise au point de l'approche vaccinale "killed but metabolically active". Sciences pharmaceutiques. 2013. ⟨dumas-00822794⟩

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