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Master Thesis

Les benzodiazépines au long cours : un facteur de risque de répétition d'intoxications médicamenteuses volontaires ?

Abstract : Introduction : long term benzodiazepine prescription seems to be at risk in some patients. In parallel, the most frequently prescribed benzodiazepines are also the most often identified in deliberate self-poisoning. Main objective : to study the relationship between long term benzodiazepine use and repeated deliberate self-poisoning. Secondary objective: to compare the psychopathological profile of chronic benzodiazepine users with no history of deliberate self-poisoning and patients repeating deliberate self-poisoning. Method : to study the patients' pharmacological path and to assess long term benzodiazepine users with no history of deliberate self-poisoning and subjects repeating deliberate self-poisoning thanks to their treatments history, their suicidal and addictological history. Their psychopathological profile will be assessed thanks to clinical evaluation scales (the MINI version 5, the BIS-11, the H scale, the TAS 20, the TCI-R, the PDQ-4+, the Goodman criteria, the "questionnaire anamnestique dérivé de l'AMDP"). Index deliberate self-poisoning will be assessed thanks to lethality (RRRS) and intentionality (SIS) questionnaires. The statistical analysis will be essentially descriptive and comparisons will be made thanks to non parametric tests. Results : the relationship between chronic benzodiazepine use and repeated deliberate self-poisoning doesn't seem to be systematic. However long term benzodiazepine use could favor the recurrence of these episodes in patients with a psychiatric history, some personality disorders, as well as more pronounced temperament and character dimensions. Conclusion : our study highlighted the necessity to accompany patients repeating deliberate self-poisoning within an actual network of healthcare professionals delivering information and prevention messages.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-00840413
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Submitted on : Tuesday, July 2, 2013 - 2:26:57 PM
Last modification on : Wednesday, July 15, 2020 - 8:56:03 AM
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  • HAL Id : dumas-00840413, version 1

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Aurélie Sarrazin. Les benzodiazépines au long cours : un facteur de risque de répétition d'intoxications médicamenteuses volontaires ?. Sciences pharmaceutiques. 2013. ⟨dumas-00840413⟩

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