Purpose: to characterize multifocal ERG parameters in patients with birdshot disease (BSCR). Methods: The mfERG was prospectively evaluated in 28 patients using Vision Monitor, Métrovision™, France (2006-2011). One eye was randomized for the statistical analysis. The correlations between mfERG parameters and visual acuity, visual field, color vision, fluorescein and indocyanine green angiography, and optical coherence tomography were studied. Twenty seven healthy subjects were matched to BSCR patients for age, axial length and lens status. Results: The mean age of the patients was 56.7 ±9.7 years, and 46.4% of the patients were male. BSCR eyes differed significantly from healthy eyes by a decrease in mean RMS (-24.7%), amplitude of P1 (-17.3%), N2 (-27.5%), and P1/N1 ratio (-26.3%) and an increase in implicit time of N1 (8.7%), P1 (5.4%). An effect of the degree of eccentricity (5 zones, figure 1) was found for RMS (p < 0.001), amplitude of P1 (p < 0.001) and N2 (p < 0.001), and implicit times of P1 (p < 0.001). RMS, P1N1 ratio, amplitudes of P1 and N2; implicit times of P1 and N1 were significantly correlated with VA, mean defect, foveal threshold, and colour vision score. When the central zone (5°: ring 1+2) was considered, RMS, amplitudes of P1, N1 and N2, and not implicit time, were significantly associated with VA, and foveal threshold ; RMS, amplitudes of N1 and P1 were significantly correlated with the FA and ICG score. Conclusion: Amplitudes and implicit times of mfERG parameters are impaired in BSCR patients and are well correlated with other anatomical and functional tests. The contribution of mfERG for the therapeutic management of patients remains to be determined.