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Master Thesis

Élaboration d'un protocole de recherche scientifique et réalisation d'une étude observationnelle visant à explorer la vasoréactivité cérébrale et le micro embolisme gazeux au cours d'une ascension rapide en haute altitude‎ : étude Cervo2 - programme européen Résamont 2

Abstract : Acute mountain sickness (AMS) affects over 70% of subjects who ascend over 4000 m. There is no predictive test for sensitive subjects before their ascent. There seems to be a correlation between dynamic cerebral autoregulation and susceptibility to AMS. This track could be considered a preventive test. Under the Franco-Italian European project ALCOTRA - RESAMONT 2, IFREMMONT wanted to undertake an observational study: CervO2, to assess the individual variability of the vascular reactivity. This study also looks at a pathophysiological hypothesis of neurological disorders in altitude: the micro gas embolism. Our task was to develop the protocol. We then saw 120 subjects in pre-inclusion visits and we chose to include 96 of these subjects. The experiment took place in three phases with three subjects each time: first phase in control in plain, then in hypobaric hypoxia of altitude after a rapid rise to the Aiguille du Midi and then after 18 hours at altitude. We studied Lake Louise's scores, cerebral vasoreactivity by transcranial ultrasonography, we were looking for patent foramen ovale and evaluation of pulmonary artery pressure. And for 1 in 3 we made a holter transcranial doppler recording. After the premature ending of the study 58 subjects were explored, it's relative success since it is the largest cohort on this subject. The results may highlight a significant difference in cerebral vasoreactivity exploitable as a marker of AMS. The Aiguille du Midi is an exceptional natural laboratory and can now be used for other studies.
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https://dumas.ccsd.cnrs.fr/dumas-00912757
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Submitted on : Monday, December 2, 2013 - 3:49:16 PM
Last modification on : Tuesday, May 11, 2021 - 11:36:16 AM
Long-term archiving on: : Monday, March 3, 2014 - 10:00:41 AM

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  • HAL Id : dumas-00912757, version 1

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Alice Gavet. Élaboration d'un protocole de recherche scientifique et réalisation d'une étude observationnelle visant à explorer la vasoréactivité cérébrale et le micro embolisme gazeux au cours d'une ascension rapide en haute altitude‎ : étude Cervo2 - programme européen Résamont 2. Médecine humaine et pathologie. 2013. ⟨dumas-00912757⟩

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