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Master Thesis

Développement d'un outil d'analyse de biomarqueurs pour le diagnostic, le pronostic et le suivi de la réponse au traitement médicamenteux du cancer de la vessie

Abstract : The advent of technologies, particularly in the field of proteomics, has improved the understanding of disease pathophysiology as well as the discovery of new biomarkers. Biomarkers show a high potential in personalized medicine in various stages such as diagnosis, treatment and follow-up. In this context, the DIPROMON project aims to improve personalization strategies in bladder cancer. The concept of patient stratification will be developed through the analysis of biomarker profiles. Stratification will be especially useful for monitoring recurrence of bladder cancer and for tailoring therapeutic interventions. Although the majority of patients develops superficial tumors, recurrence rate is high and affects 50 to 70% of patients. One of the main consequences of recurrence is regular monitoring for most patients. The work presented in this report relates to the development of a high-throughput and multiplex test for detection and quantification of biomarkers, which will be part of the technological platform developed in the DIPROMON project. The development of the protein chip started with three interleukins (IL6, IL8 and IL10) which are detected and quantified by a sandwich immunoassay. The test has undergone several optimization steps but the analytical validation is not completed yet. The final analysis tool will be more complex as other markers selected by the project partners will be added. It will then require a clinical validation, including a pilot study.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-00918457
Contributor : Jean-Hugues Morneau <>
Submitted on : Friday, December 13, 2013 - 3:41:21 PM
Last modification on : Wednesday, July 15, 2020 - 8:56:03 AM
Long-term archiving on: : Tuesday, March 18, 2014 - 12:45:10 PM

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  • HAL Id : dumas-00918457, version 1

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Marine de Paoli. Développement d'un outil d'analyse de biomarqueurs pour le diagnostic, le pronostic et le suivi de la réponse au traitement médicamenteux du cancer de la vessie. Sciences pharmaceutiques. 2013. ⟨dumas-00918457⟩

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