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Master Thesis

Effet de la restriction alimentaire et de la dégradation de l'hygiène sur la réponse inflammatoire chez le lapin en post-sevrage

Abstract : In breeding, antibiotic treatment is frequently used after weaning to fight against digestive disorders of the young (piglet or rabbit). The recent recommendations to decrease the medication in breeding require to find alternatives to insure health of animals. A research project was developed, to understand the immune mechanisms associated to two parameters of the conduct of breeding in post-weaning : feed restriction, which reduces entéropathies to the rabbit, and poor sanitary conditions, which are unfavorable to health. This report establishes a part of this project, and analyzes the inflammatory answer of weaned rabbits, fed ad libitum (AL) or restricted to 70% of AL, and raised in two sanitary conditions : good vs poor, defined by a cleaning before and during the experiment for the first case and none of these practices for the second case. The feed restriction showed a reduction from 30 to 50% of the expression of pro-inflammatory cytokines IL-6, IL-8, IL-1β, IL-17 and TNFα in the ileum, a reduction of 30 and 40% of IL-17 and IL-1β respectively in the spleen and of 25% of IL-17 in the caecal appendix. The poor sanitary conditions, which were not defined by a significant increase in microbial population, showed no effect. In conclusion, the intestinal inflammatory response, decreased by feed restriction, could explain the best resistance to digestive disorders of young rabbit and consequently a reduction in the mortality.
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Master Thesis
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Submitted on : Thursday, March 13, 2014 - 4:36:33 PM
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Marie Hauteclaire Furbeyre. Effet de la restriction alimentaire et de la dégradation de l'hygiène sur la réponse inflammatoire chez le lapin en post-sevrage. Sciences agricoles. 2013. ⟨dumas-00958918⟩

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