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Master Thesis

Perte de poids à l'officine‎ : intérêts et limites du glucomannane et de l'acide linoléique conjugué

Abstract : The market for slimming supplements is constantly expanding. This increase can be explained partly by the increasing number of overweight people around the world, but also by the culture of the perfect body and an ideal weight to achieve, under pressure from the media in the country Westerners. Among the active ingredients in dietary supplements, two are widely represented: glucomannan and conjugated linoleic acid. Glucomannan is a soluble fiber with an "appetite suppressant" effect and it contributes to weight loss, in combination with a reduced calorie diet. These effects have been validated by EFSA. It also has a beneficial effect on the cholesterol level and is well tolerated in adults. In contrast, the effects of conjugated linoleic acid on weight loss, have not been validated by EFSA. This conjugated fatty acid acts on the lipid metabolism by promoting fatty acids oxidation, leading to a decrease in fat mass with or without an increase in lean mass. It is marketed as a combination of isomers, and its effects are isomer-dependent. Due to the risk of insulin resistance associated with the isomer t10, c12, additional clinical trial are needed to better understand the mechanism of action of this fatty acid as a combination of isomers or isomer only, but also to evaluate its safety, especially in the diabetic population. Faced with the current craze for slimming supplements, the notion of security must be put forward by the industrial pharmacist to preserve and improve the health of the patient.
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Master Thesis
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Submitted on : Monday, March 17, 2014 - 9:12:24 AM
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  • HAL Id : dumas-00959385, version 1
  • PPN : 176717668


Karima Braham. Perte de poids à l'officine‎ : intérêts et limites du glucomannane et de l'acide linoléique conjugué. Sciences pharmaceutiques. 2014. ⟨dumas-00959385⟩



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