Skip to Main content Skip to Navigation
Master Thesis

Hyperendémie d'infection invasive à méningocoque B : description de la série de cas de la souche B:14:P1-7,16 dans le Béarn et état des lieux à un an du plan de vaccination ciblée

Abstract : Introduction: Between July 2012 and April 2013, six cases of invasive meningococcal B:14:P1-7,16 were authenticated in the Pyrénées-Atlantiques. High rate of local attack led to a targeted vaccination in townships and Lagor Navarrenx from June 2013 to 6911 persons aged 2 months to 24 years to limit the spread of this virulent strain. Material and Methods: crossing data CNRM and ARS Aquitaine, we found in the medical records of Pau hospital epidemiological, clinical and biological serie's cases that led to the vaccination. The membership data vaccine were provided by ARS. Results: Subjects were boys under 10 years old. Fever was extended to more than 12 hours before admission to the hospital. A subject died. PCR confirmation was made on blood except for one case of joint fluid. 2 confirmed cases and 3 possible occurred after vaccination. At one year, 1585 people had received at least one dose of vaccine or a membership rate of 23% and 1058 have made the full presentation, while the target vaccination coverage was 70%. Discussion: clinico-biological parameters of initial cases are comparable to large national and international series of IMD. Failure of vaccine accession was multifactorial: unfavorable time of year, practice organization, heterogeneous population, distrust of vaccines, low numbers of cases and lack of information were the main determinants. Conclusion: Although the rate of vaccination coverage was insufficient, only one case occurred in the area including the two townships and allowed campaign stop after one year. The posterior monitoring campaign will be critical to monitor the persistence of cases, and the rate of vaccination with the vaccine launched Bexsero©, with an AMM without being registered in the immunization schedule.
Document type :
Master Thesis
Complete list of metadata

Cited literature [62 references]  Display  Hide  Download

https://dumas.ccsd.cnrs.fr/dumas-01095313
Contributor : Bu Carreire Université de Bordeaux <>
Submitted on : Monday, December 15, 2014 - 2:13:13 PM
Last modification on : Wednesday, August 23, 2017 - 4:30:55 PM
Long-term archiving on: : Monday, March 16, 2015 - 11:40:47 AM

Identifiers

  • HAL Id : dumas-01095313, version 1

Collections

Citation

Justine Roux. Hyperendémie d'infection invasive à méningocoque B : description de la série de cas de la souche B:14:P1-7,16 dans le Béarn et état des lieux à un an du plan de vaccination ciblée. Médecine humaine et pathologie. 2014. ⟨dumas-01095313⟩

Share

Metrics

Record views

133

Files downloads

535